Two ways to read a genome: Scientists reveal the first body-wide, single-cell atlas that maps DNA folding and epigenetics together
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Oct-2026 07:15 ET (29-Oct-2026 11:15 GMT/UTC)
Salk scientists and collaborators publish the first single-cell atlas to simultaneously map 3D genome architecture and DNA methylation across the human body—86,689 cells spanning 16 tissues, 35 major cell types, and 206 subtypes. The atlas pinpoints cell types where epigenetic features overlap with genetic risk for conditions including atrial fibrillation, bipolar disorder, schizophrenia, and blood-glucose regulation, helping explain how non-coding DNA variants may contribute to disease. All data are freely available through an interactive browser, providing a reference for gene-regulation research and a training resource for AI models that predict the impact of genetic variants.
Before entering a long decline that continues into the present, humanity may have spoken far more languages, experiencing a “golden age” of linguistic diversity, with tens of thousands of languages spoken worldwide only several thousand years ago, according to a new study. Human language is extraordinarily diverse, with roughly 7,500 signed and spoken in the world today. However, this diversity has been steadily eroding for centuries as a small number of dominant languages have spread worldwide. Today, nearly half of all languages are endangered, and at least four are lost each year. Because written records extend back only about 6,000 years, the long-term patterns of linguistic diversity across much of human history remain largely unknown. To reconstruct the history of the world's languages over the past 12,000 years, Damián Blasi and colleagues developed a demographic model using ethnographic data from 171 hunter-gatherer societies as a proxy for early human populations. Because these small, culturally cohesive groups typically spoke a single language, the model used their sizes, together with estimates of ancient global population, to infer the likely number of languages in the early Holocene. The model assumes that as agriculture and technological advances allowed populations to grow, increasing numbers of people came to share the same language, causing language diversity to grow more slowly than the human population.
According to Blasi et al., the approach provides a quantitative framework for reconstructing the long-term history of the world's languages despite the lack of direct historical evidence. The findings estimate that the world likely had fewer languages 12,000 years ago than it does today, contradicting the idea that linguistic diversity has steadily declined since the end of the last Ice Age. Instead, the number of languages appears to have increased alongside growing human populations, peaking between 1,000 and 3,000 years ago, when the world may have supported tens of thousands of languages. The model suggests that this "golden age" of linguistic diversity was followed by an exceptionally rapid collapse over the past two millennia, as expanding societies increasingly replaced smaller language communities. According to the authors, the findings indicate that today's language crisis is the culmination of a long-term process of cultural homogenization driven by the expansion of human population rather than a consequence of colonialism alone.
In mammals, males are usually stronger and more competitive than females. Males also show greater inequality in reproductive success – the number of offspring they produce – than females. In spotted hyenas, the opposite is true: reproductive inequality is greater in females than in males. The reason? Female spotted hyenas pass on their social rank and the associated privileges such as priority access to food to their offspring, whereas males do not. These are the findings of a new study on spotted hyenas spanning eight generations across eight clans in the Ngorongoro Crater in Tanzania, carried out by the Ngorongoro Hyena Project of the Leibniz Institute for Zoo and Wildlife Research in Berlin (Leibniz-IZW) and the Institut des Sciences de l’Évolution de Montpellier (ISEM). The study is published in the journal “Science Advances” and may explain why females are the more competitive sex in some species.
A study by Sapienza University, the Italian Institute of Technology (IIT), EY and IRCCS Fondazione Santa Lucia used virtual reality to measure interpersonal distance in 184 Italian and Japanese participants. The research was conducted during two major international public events: Expo 2025 in Osaka, Japan, and Maker Faire Rome, Italy. The findings reveal how culture, first impressions and implicit biases shape our personal space. The study has been published in Computers in Human Behavior.
An international study led by researchers from the Institute of Environmental Science and Technology at the Universitat Autònoma de Barcelona (ICTA-UAB) reveals that Indigenous, African and Afro-descendant communities relied more heavily on marine resources, while communities of immigrants from Germany consumed mainly plant species and terrestrial products.