A new Dartmouth study finds that many of Syria's archaeological sites were damaged during Syria's civil war not just by looting but that, in areas occupied by the Turkish military, sites were systematically bulldozed. The findings are published in the journal Heritage.

Salk scientists identify two cellular programs linked to age-related dysfunction, ferroptosis and senescence, are mechanistically linked through the enzyme acid ceramidase. The team finds that senescent “zombie” cells are more vulnerable to regulated cell death through ferroptosis and that they can pass that sensitivity on to neighboring cells. The observations suggest acid ceramidase could be a powerful therapeutic target for supporting healthy aging and preventing age-related diseases and disorders such as arthritis, dementia, and cancer.

Salk scientists and collaborators publish the first single-cell atlas to simultaneously map 3D genome architecture and DNA methylation across the human body—86,689 cells spanning 16 tissues, 35 major cell types, and 206 subtypes. The atlas pinpoints cell types where epigenetic features overlap with genetic risk for conditions including atrial fibrillation, bipolar disorder, schizophrenia, and blood-glucose regulation, helping explain how non-coding DNA variants may contribute to disease. All data are freely available through an interactive browser, providing a reference for gene-regulation research and a training resource for AI models that predict the impact of genetic variants.