Highlights

•The review explores a strong correlation between gut microbiome dysbiosis and colorectal cancer (CRC) development.

•Major metabolite changes show increased glycolysis, fatty acids, lipogenesis, and glutaminolysis.

•Diet influences the gut microbiome, which in turn impacts CRC development.

•Manipulating gut microbiota and adding prebiotics, probiotics, and diet therapy may help restore microbial balance.

Nearly half of patients who completed an at-home test for colorectal cancer fail to repeat the screening consistently, according to Rutgers Health researchers who also found primary care provider behaviors can increase patient consistency – and catch more cancers early.

Cell therapies show encouraging results for a deadly brain infection, advanced kidney cancer

Tumor immune microenvironment studies reveal clues to colorectal cancer recurrence, multiple myeloma and oral cancer progression, and how T cells eliminate AML

KRAS inhibitors demonstrate promise as targeted therapy for rare appendix cancer, novel epigenetic therapy displays activity in treatment-resistant AML

Researchers develop a new way to isolate the strongest cancer-fighting immune cells

New insights reveal how fasting improves intestinal recovery after radiation

Researchers at the Keck School of Medicine of USC have identified a biological feedback loop that helps explain why certain colorectal cancers—known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) tumors—respond better to immunotherapy. Using mouse models and patient tumor data, the team found that two genes, DR5 and Lig3, drive a cycle of tumor cell death and immune activation by promoting the release of extrachromosomal circular DNA, which amplifies the immune response. Tumors with higher DR5 and Lig3 activity were more likely to respond to immune checkpoint inhibitors, suggesting a potential pathway to improve treatment and better predict which patients will benefit from immunotherapy.