Experimental HIV vaccine achieves a long-sought goal
Peer-Reviewed Publication
This September, we're exploring the science behind vaccines. From how they train our immune systems to fight disease to the research shaping their future, vaccines offer an opportunity to discover the science helping protect individuals and communities around the world.
Updates every hour. Last Updated: 22-Oct-2026 21:16 ET (23-Oct-2026 01:16 GMT/UTC)
For years, researchers have been hoping for vaccines that protect people against not just one strain of HIV, but every strain of the quickly mutating virus. This requires a vaccine that coaxes the human body to develop something called broadly-protective antibodies—molecules that recognize a broad range of HIV strains. Now, scientists at Scripps Research and Sweden's Karolinska Institute have developed an experimental vaccine that leads to broadly protective HIV antibodies in every rhesus macaque tested.
In a new study published in Nature Immunology, researchers at Boston Children’s Hospital demonstrated that pairing the original COVID-19 mRNA vaccine with an immune system enhancer, known as an adjuvant, improved the duration of the vaccine’s protection in mice. The combo also showed a more pronounced response against omicron viral components than the vaccine alone. The researchers say that introducing adjuvants like this one to mRNA vaccines may alleviate the need for frequent boosters due to waning antibodies or new viral variants.