Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, and approximately 90% of cases are caused by progerin. Progerin is toxic and causes diverse abnormalities. More and more studies show that progerin is also detected in physiological aging and chronic kidney disease (CKD). Thus, targeting progerin clearance shows powerful potential for the treatment of HGPS, CKD and aging-related diseases. Now, Zhang group from Peking University and Kunming University of Science and Technology, reports that activating lysosome biogenesis can promote progerin clearance and alleviate cellular senescence in HGPS. They identify lysosome defects as a prevalent feature in HGPS, which impairs progerin clearance, and reveal that activating lysosome biogenesis can counteract lysosome defects and accelerate progerin clearance and mitigate DNA damage, cell cycle arrest, low proliferation ability and senescence-associated secretory phenotype (SASP) in HGPS cells. The findings highlight the vital role of lysosomes in progerin clearance, and uncover the potential of targeting lysosome biogenesis in anti-senescence.

Scientists find that nanofiltration (NF) membrane technologies, unlike other pressure-driven filtration systems, can be tailored to effectively treat wastewater contaminated with a wide array of pharmaceutical compounds.

A new material might contribute to a reduction of the fossil fuels consumed by aircraft engines and gas turbines in the future. A research team from Karlsruhe Institute of Technology (KIT) has developed a refractory metal-based alloy with properties unparalleled to date. The novel combination of chromium, molybdenum, and silicon is ductile at ambient temperature. With its melting temperature of about 2,000 degrees Celsius, it remains stable even at high temperatures and is at the same time oxidation resistant. The results are published in the “Nature” journal. (DOI: 10.1038/s41586-025-09516-8)

The article highlights how integrated platforms—especially within scanning electron microscopes (SEM)—are enabling multi-degree-of-freedom, closed-loop nano-robots capable of precise assembly and manufacturing at the atomic scale. These advances pave the way for breakthroughs in quantum devices, nanomedicine, and advanced materials.