Drug-drug interactions (DDI) can cause adverse drug reactions during the co-administration of multiple drugs, necessitating accurate and scalable prediction tools. While deep learning models have shown promise recently, most models show poor performance against drugs not encountered during training. Now, researchers have developed a lightweight and scalable model, called DDINet, designed specifically to predict unseen drug interactions. This innovative model achieves superior accuracy in predicting interactions for unseen drugs, with potential for practical deployment.

In new results from a clinical trial, researchers show that electrical stimulation of the spinal cord can restore the muscle control and sensory feedback required for coordinated walking movements.

Rice University researchers Jianwei Huang and Ming Yi have developed a new capability, magnetoARPES, building on angle-resolved photoemission spectroscopy (ARPES) that allows researchers to study quantum behaviors they have been unable to resolve using ARPES alone. 

New research from the University of Oxford published today (11 March) shows that cold snaps and heavy rain can stunt growth and reduce survival prospects in UK great tit nestlings. However, breeding earlier within a season appears to buffer against many of these weather-related effects.

A multi-disciplinary research team at the Wyss Institute at Harvard University, Dana-Farber Cancer Institute, and collaborating institutions leveraged their recently developed highly versatile DoriVac DNA origami nanotechnology that is both vaccine and adjuvant as an alternative to current vaccine platforms. As published in Nature Biomedical Engineering, DoriVac vaccines made with different viral antigens produce potent antigen-specific antibody-mediated and T cell-mediated responses in mice as well as in a forward-looking pre-clinical in vitro model of the human lymph node engineered using the Wyss Institute’s microfluidic human Organ Chip technology. The findings are published in Nature Biomedical Engineering.

POSTECH and Pukyong National University researchers develop a conductive bioglue that seamlessly integrates tissues and electronic devices in the fluid‑filled body.