A research paper by scientists at Wenzhou Medical University developes a mannose-modified pH/glutathione (GSH) dual-responsive nano-delivery system (MPP@IKE-aPD-1/diABZI) that synergistically activates ferroptosis and immune responses to achieve efficient antitumor therapy.

A new study published in Big Earth Data evaluates ten satellite-based and reanalysis precipitation datasets available in Google Earth Engine using rain gauge observations across Czechia from 2001 to 2021. The results show that the gauge-adjusted GSMaP dataset provides the highest overall accuracy, while ERA5-Land performs well for long-term analyses despite systematic overestimation. The findings offer clear guidance for selecting reliable precipitation datasets for hydrological, climate, and environmental applications, particularly in regions with complex terrain.

Associate Professor Yuichiro Matsushita of Materials and Structures Laboratory, Institute of Science Tokyo, Mitsubishi Electric Corporation, Associate Professor Takahide Umeda of Institute of Pure and Applied Sciences, University of Tsukuba and Quemix Corporation  announced today that they have achieved the world’s first¹ elucidation of how hydrogen produces free electrons² through the interaction with certain defects³ in silicon. The achievement has the potential to improve how insulated gate bipolar transistors (IGBTs) are designed and manufactured, making them more efficient and reducing their power loss. It is also expected to open up possibilities for future devices using ultra-wide bandgap (UWBG) materials.⁴

Secondary lymphedema, a chronic condition caused by lymph node removal during cancer surgery, leads to swelling, pain, and reduced mobility with limited treatment options. In a recent study, researchers from Japan developed a centrifugal cell stacking technique to create artificial lymphatic tissues that can restore lymphatic flow. When transplanted into mice, CeLyTs form functional lymph node-like structures that reduce swelling and promote lymph flow, offering a promising therapeutic strategy for lymphedema.

Large language models (LLMs) play a key role in advancing intelligent healthcare. While LLMs are increasingly applied in medical fields such as disease screening, diagnostic assistance, and health management, there are no evidence-based guidelines for assessing their effectiveness in healthcare. Now, researchers have developed a consensus that provides a systematic and evidence-based evaluation framework to assess effectiveness of LLMs in medical applications. The framework includes scientific evaluation metrics and procedures, providing guidance for model evaluators.