Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development in mice. In the new study, published in Nature Communications, a single-letter insertion in a non-coding regulatory region caused XX mice, which would normally develop as females, to develop instead as males with testis and male genitalia.

A review in Glycoscience & Therapy summarizes advances in selective editing of N-glycan signals on living cell surface via the LCS‑NGS technology platform. It focuses on enzyme‑based strategies (glycosyltransferases and glycosidases) that enable precise, real‑time N‑glycan manipulation while preserving cell viability. Applications in tumor targeting, immune regulation, and cell therapy are highlighted. Importantly, glycan signals as a"biological quick recognition (BioQR)" hypothesis proposed—that glycan signals act as rapid markers for species, tissues, and disease states. Current limitations and future directions are also discussed.

Researchers from China developed the first high-density 10K SNP array for wax gourd using genotyping by target sequencing (GBTS) technology, comprising 10,722 genome-wide SNPs distributed across the genome, including 278 associated with functional trait loci.

First development of a RT-ERA/CRISPR-Cas12a platform for rapid and visual detection of Epizootic Hemorrhagic Disease Virus (EHDV), enabling on-site diagnosis within 1 h without specialized equipment.

When you build a structure, the materials matter. The poorer the materials, the less reliable  the structure. Databases are no different, and with the rise of AI-driven discovery, the importance of feeding highly reliable data has gained added salience. A new study has examined the database architecture being used in materials science to see how it impacts the reliability and vitality of research results.