Researchers developed ShapKAN, a deep learning model integrated into the AI4Min-PE platform (http://pe.ai4mineral.com), enabling instant prediction and visualization of key thermodynamic parameters up to 500 GPa. This open AI tool supports the discovery of new chemical behaviors of minerals and elements under extreme conditions.

High-density tactile sensor arrays are essential for next-generation electronic skins, yet increasing array density inevitably amplifies lateral strain–induced mechanical crosstalk, which severely undermines signal stability, recognition reliability, and long-term service performance—particularly in dynamic applications such as Braille reading. Here, researchers report a capacitive tactile array incorporating a gradient-modulus strain isolation layer that decouples mechanical functions along the thickness direction, effectively suppressing nonlocal strain transfer while maintaining high sensitivity. Guided by quantitative structural design principles supported by simulation and experiment, the device achieves a sensitivity of 3.92 kPa⁻¹ with a crosstalk coefficient of only 4.39%. Integrated into a “sliding–recognition–speech” Braille platform, it achieves 100% static and 99% dynamic recognition accuracy while reducing false triggers by over 70%. This work demonstrates that structural suppression of mechanical crosstalk is a powerful pathway to ensuring the stable, reliable operation of high-density electronic skins and offers a scalable design strategy for future assistive tactile perception technologies.

Recently, a research team led by Professor Zhang Jiachao from the College of Food Science and Engineering, Hainan University, published a new study in Science Bulletin entitled “Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects in a type 2 diabetes model.” This study directly addresses the long-standing challenge of the “microbial drug black hole” in the pharmacotherapy of metabolic diseases. The team successfully identified a tropical probiotic strain with dual “efficacy-enhancing and toxicity-reducing” properties, Bifidobacterium animalis subsp. lactis B960 (B960). For the first time, the researchers systematically elucidated the molecular mechanism by which this strain produces the functional metabolite Calenduloside E to synergistically enhance the therapeutic efficacy of glibenclamide while mitigating its adverse effects. Importantly, these findings were further validated using a human-derived gut–liver interconnected organ-on-a-chip platform that recapitulates key aspects of the human physiological microenvironment in vitro. Overall, this work provides an innovative strategy for the development of probiotic-based adjuvant therapies for the treatment of type 2 diabetes.