Engineering the development of the pancreas
Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)Peer-Reviewed Publication
Tissue engineering the pancreas: Working with three-dimensional pancreatic models (organoids), derived from mouse cells, researchers combined computer simulations with experiments to find out what controls the shape of lumens (fluid-filled cavities) during the development of the pancreas.
Proliferation, Pressure, Permeability: The shape of the lumen depends on the balance between the cell proliferation rate and the pressure in the lumen. Low pressure and high proliferation produce more complex or ‘star-shaped’ lumens. The pressure in lumens remain low because the surrounding pancreatic tissue is permeable.
Implications for organ development and disease: The discovered mechanisms can be potentially relevant to other organs with complex ductal systems and to common cystic diseases. Furthermore, these findings could be used to develop new therapeutic strategies, including testing the effects of drugs for diseases.
- Journal
- Nature Cell Biology
- Funder
- Max-Planck-Gesellschaft