Monte Carlo-consistent dose prediction for clinical CyberKnife radiotherapy using a physics- and spatially-informed diffusion model
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Oct-2026 16:16 ET (29-Oct-2026 20:16 GMT/UTC)
A physics- and spatially informed diffusion model was developed to achieve rapid Monte Carlo–consistent dose prediction for CyberKnife radiotherapy. The model integrates finite-size pencil beam dose distributions, planning CT images, and signed distance maps to incorporate physical, anatomical, and spatial prior information. PSIDMViT improved agreement with Monte Carlo reference doses across head-and-neck, lung, and liver cancer cases. The model reduced the time required for Monte Carlo–consistent dose estimation from approximately one hour to about 18 minutes, supporting more efficient high-precision radiotherapy planning and verification.
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