Alveolar bone defects can cause periodontal dehiscence, leading to exposure of dental roots, recession of gums, and increased tooth sensitivity. In a new study, researchers have evaluated the therapeutic potential of abaloparatide (ABL), a synthetic analog of human parathyroid hormone-related protein(PTHrP), in alleviating periodontal dehiscence. Utilizing rat models undergoing orthodontic tooth movement, they demonstrate that submucosal injection of ABL induces alveolar bone formation through a focal adhesion kinase(FAK)-driven mechanism.

Neural Radiance Fields (NeRF) is a machine learning technique that can create 3D reconstructions of a scene from 2D images captured from multiple angles, representing it from entirely new perspectives. While well established for static images, existing methods struggle when using monocular videos as input due to motion blur. Now, researchers have developed MoBluRF: a two-stage framework that enables creation of accurate, sharp 4D (dynamic 3D) NeRFs from blurry videos, captured from everyday handheld devices.

A collaborative research team from Peking University has developed a novel method to enhance the tumor-targeting efficiency of γδ T cells through chemical engineering. By conjugating or gluing the cancer cell-targeting antibodies to γδ T cells via fast metabolic glycan labeling and click chemistry, the team achieved improved anti-tumor efficacy both in vitro and in vivo. This innovative approach holds significant promise for advancing adoptive cell therapy in cancer treatment.

Research teams from Tsinghua University and Anhui University of Technology have developed a novel post-processing technique using hot isostatic pressing (HIP) to improve the microstructure and wear resistance of titanium alloy surfaces. Through a careful combination of temperature and pressure, the team achieved remarkable reductions in residual stress-up to eightfold-and enhanced mechanical properties, including increased hardness and ductility. This fabrication process promotes better phase stability and interfacial bonding, enabling the coated titanium components to withstand extreme temperatures and harsh environments more effectively. This technology effectively overcomes the long-standing challenge of poor wear resistance in titanium alloys, offering a solid theoretical foundation and valuable technical guidance for the laser in-situ fabrication of TiN/Ti composite surface modification layers. The outcomes of this work hold significant potential to transform industries such as aerospace, biomedical implants, and industrial tooling—paving the way for more durable, reliable, and high-performance titanium-based components.

The rain delays, sorghum withers; when a storm finally breaks, complaints rise again. To break this cycle of uncertainty, scientists from the Alliance of Bioversity International and CIAT, INERA, and the University of Ghana conducted the first large-scale survey on agricultural climate services in Burkina Faso, Ghana, Mali, and Senegal. Published in Frontiers in Climate, the study analyzes the expectations of 1,212 farmers and charts a credible path to turn weather reports into a profitable investment.