Astronomers from Chalmers University of Technology, Sweden, have discovered a vast and expanding bubble of gas and dust surrounding a red supergiant star – the largest structure of its kind ever seen in the Milky Way. The bubble, which contains as much mass as the Sun, was blown out in a mysterious stellar eruption around 4000 years ago. Why the star survived such a powerful event is a puzzle, the scientists say.

The new results are published in the scientific journal Astronomy and Astrophysics, and the team was led by Mark Siebert, Chalmers, Sweden. Using the ALMA radio telescope in Chile, the researchers observed the star DFK 52 – a red supergiant similar to the well-known star Betelgeuse.

For researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign, a new avenue for reducing carbon emissions can be found on the side.

Macromolecular-based gene delivery systems have emerged as viable alternatives to non-viral vectors for gene therapy due to their versatility, biocompatibility, and capacity to efficiently deliver therapeutic cargo. These systems, primarily based on synthetic and natural polymers, offer significant advantages in terms of safety, controlled gene release, and targeted delivery. This review explores the design and synthesis of macromolecular carriers, focusing on their chemical and physical architectures, which play a key role in improving gene delivery. Catanionic polymers and their derivatives (comb, brush, and star polymers) have been extensively researched for their capacity to condense and protect genetic material. Furthermore, natural polymers like chitosan and hyaluronic acid have been modified to enhance gene delivery capabilities. These macromolecular carriers are engineered to boost circulation time, increase cellular uptake, and facilitate the controlled release of genetic material at the target site. Strategies such as incorporating targeting ligands, stimuli-responsive elements, and reducing cytotoxicity are being pursued to improve the overall efficiency and specificity of these systems. This review highlights the current state of macromolecular gene delivery systems, their applications, and the ongoing research aimed at overcoming existing challenges, paving the way for more effective non-viral gene therapies.