Breakthrough in intractable intestinal disease treatment using xenogeneic-free intestinal stem cells
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Jun-2026 01:16 ET (11-Jun-2026 05:16 GMT/UTC)
The therapeutic use of human calcitonin (CT) in humans is limited by rapid receptor desensitization (tachyphylaxis), which requires short-term dosing despite the need for long-term treatment. In contrast, fish CT-CT receptors (CTR) exhibit extraordinary resistance to desensitization, enabling lifelong calcium regulation in high-Ca2+ marine environments. Here, we analyze the evolutionary, structural, and functional distinctions between fish and human CT systems. We propose that the unique molecular structure of fish CT and CTR may provide templates for engineering durable therapeutic agents to overcome tachyphylaxis.
A joint research team from NIMS, Tokyo University of Science, and Kobe University has developed a new artificial intelligence (AI) device that exploits ion behavior to perform information processing. The team succeeded in reducing the computational load to about 1/100 of that required for conventional deep learning. The technology is expected to contribute to enhancing the information processing performance of "edge AI" operating directly on terminal equipment (an edge device). This research was published in ACS Nano on October 14, 2025.
New research from Fujita Health University reveals that talking can subtly delay the eyes’ ability to detect and stabilize on visual information. In experiments comparing talking, listening, and control conditions, only talking caused slower reaction, movement, and fixation times during rapid eye-movement tasks. Because driving depends heavily on fast gaze shifts, these delays may impair hazard detection and slow physical responses. The findings highlight the hidden risks of engaging in conversation while driving.