Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups and promotes tumor cell proliferation in pancreatic ductal adenocarcinoma, report researchers from Institute of Science Tokyo, Japan. Administration of PAD inhibitors reduced PRUNE1 expression and suppressed tumor cell proliferation in both pancreatic cancer cell lines and mouse models. The study thus lays the foundation for future anticancer therapies targeting PAD2 enzymatic activity.

Hydrogel-based devices—such as hydrogel pores—are widely used in miniaturized applications ranging from drug delivery to flexible electronics and robotics. Yet conventional designs with simple geometries often suffer from slow, unpredictable actuation and offer limited control. In a recent study, researchers introduced an origami-inspired “facet-driven folding” strategy using polygonal hydrogel pores to deliver highly controlled, programmable actuation, opening new possibilities for selective drug delivery and information encryption.

Switchable underwater adhesion is desirable for various robotic applications. Recently, a team of researchers from SEOULTECH have proposed a novel hydrogel-based starfish-inspired tube foot that enables temporary yet strong underwater adhesion and transportation. Its underlying mechanism utilizes pressure difference or suction, with pneumatic actuation as the detachment trigger. This innovation is expected to revolutionize display manufacturing technology as well as biomedical engineering.

Metal–carbon dioxide (CO₂) batteries hold great promise for reducing greenhouse gas emissions and are regarded as one of the most promising energy storage techniques due to their efficiency advantages in CO₂ recovery and conversion. Moreover, rechargeable nonaqueous metal–CO₂ batteries have attracted much attention due to their high theoretical energy density. However, the stability issues of the electrode–electrolyte interfaces of nonaqueous metal–CO₂ (lithium (Li)/sodium (Na)/potassium (K)–CO₂) batteries have been troubling its development, and a large number of related research in the field of electrolytes have conducted in recent years. This review retraces the short but rapid research history of nonaqueous metal–CO₂ batteries with a detailed electrochemical mechanism analysis. Then it focuses on the basic characteristics and design principles of electrolytes, summarizes the latest achievements of various types of electrolytes in a timely manner and deeply analyzes the construction strategies of stable electrode–electrolyte interfaces for metal–CO₂ batteries. Finally, the key issues related to electrolytes and interface engineering are fully discussed and several potential directions for future research are proposed. This review enriches a comprehensive understanding of electrolytes and interface engineering toward the practical applications of next-generation metal–CO₂ batteries.

Triboelectric nanogenerators (TENGs) offer a self-sustaining power solution for marine regions abundant in resources but constrained by energy availability. Since their pioneering use in wave energy harvesting in 2014, nearly a decade of advancements has yielded nearly thousands of research articles in this domain. Researchers have developed various TENG device structures with diverse functionalities to facilitate their commercial deployment. Nonetheless, there is a gap in comprehensive summaries and performance evaluations of TENG structural designs. This paper delineates six innovative structural designs, focusing on enhancing internal device output and adapting to external environments: high space utilization, hybrid generator, mechanical gain, broadband response, multi-directional operation, and hybrid energy-harvesting systems. We summarize the prevailing trends in device structure design identified by the research community. Furthermore, we conduct a meticulous comparison of the electrical performance of these devices under motorized, simulated wave, and real marine conditions, while also assessing their sustainability in terms of device durability and mechanical robustness. In conclusion, the paper outlines future research avenues and discusses the obstacles encountered in the TENG field. This review aims to offer valuable perspectives for ongoing research and to advance the progress and application of TENG technology.

Macquarie University researchers used CRISPR technology to challenge textbook explanations for why albinism is rare in nature