Tumor cells exploit chemokine signaling to construct an immunosuppressive microenvironment that resists anti-tumor immune responses. A new review systematically maps the chemokine-receptor network in the tumor microenvironment and introduces a three-part “3D” targeting strategy: Decrease recruitment of suppressive cells (Tregs, MDSCs, TAMs), Develop effector T cell and NK cell function, and Dismantle physical and signaling barriers that exclude effectors from tumors. This framework ultimately provides a roadmap for precision combination immunotherapy to overcome immune evasion

As AI is being widely tested in medicine, scientists at the University of Auckland, Auckland City Hospital, and Matai Medical Research Institute in New Zealand have analyzed the current landscape of AI models for meningioma (a cancer of the brain’s soft cover) segmentation from MRI scans, and its path ahead. Their key finding is that advanced model architecture has considerably contributed to tumor detection sensitivity, rather than data characteristics, imaging modalities, or preprocessing.  

Researchers have developed a copper-based metal-organic framework that converts CO₂ into N-formamides in a fully light-driven tandem process. The system combines CO₂ reduction and C-N coupling without Pd metal, external heating or high pressure.

Dendritic mesoporous silica-lanthanide fluoride (DMS-CeF₃:Tb) nanocomposites with a pomegranate-like architecture have been fabricated through a facile in situ enrichment strategy. The strong single-particle luminescence and long photoluminescence lifetime of DMS-CeF₃:Tb nanoprobes enabled an ultrasensitive immunoassay for prostate specific antigen (PSA) with a detection limit of 41 fg mL^-1, which represents a 976-fold improvement over a commercial PSA enzyme-linked immunosorbent assay kit. Validation with PCa serum samples revealed a strong correlation with the hospital’s electrochemiluminescence immunoassay, confirming the clinical applicability of the nanoprobes. Additionally, targeted imaging and in vitro detection of cervical cancer cells were realized utilizing biotinylated DMS-CeF₃:Tb nanoprobes, enabling rapid cancer screening. These findings reveal the great potential of DMS-CeF₃:Tb as an efficient nano-bioprobe for early cancer diagnosis.

In a new study published in China Welding, researchers have optimized pulse frequency in local dry underwater laser welding (LDU-LW) of Q355B steel. The optimized pulsed laser process significantly improves weld formation, mechanical properties and corrosion resistance, offering a reliable solution for underwater repair and manufacturing of marine engineering structures.