Near-infrared II (NIR-II) photoacoustic imaging (PAI) technology is an emerging biomedical imaging modality characterized by high spatial resolution, deep tissue penetration, and high signal-to-noise ratio. NIR-II PAI enables highly clear real-time monitoring of various physiological and pathological processes and visualizes different biological entities, making it crucial for advancements in life sciences and medicine. NIR-II PAI technology holds significant application potential in disease diagnosis and treatment, particularly in early diagnosis, precise localization, boundary delineation, and monitoring of treatment response for tumors and other conditions. By combining with multimodal or diagnostic-therapeutic integrated molecular probes, this technology enables accurate disease localization and guided treatment, which is crucial for early diagnosis and therapy. This review provides a detailed overview of research progress on NIR-II PAI probes, discussing the emergence and latest developments of various NIR-II PAI probes and their applications in early diagnosis and treatment of tumors, cerebrovascular systems, inflammation, and other tissues. Additionally, it summarizes the development status of these probes and outlines future prospects and challenges.

POSTECH research team accelerates stretchable technology commercialization with world's first visualization of serpentine structures.

POSTECH research team led by Professor Jihyun Hong develops manganese-based cathodes with longer lifespan by suppressing oxygen release.

Professor Sangmin Lee from POSTECH’s Department of Chemical Engineering, in collaboration with 2024 Nobel Chemistry Laureate Professor David Baker from the University of Washington, has developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI). Their pioneering research was published in Nature on Dec. 18.

The U.S. Department of Energy has selected the Princeton Plasma Physics Laboratory to receive two prestigious Microelectronics Science Research Center. The DOE program leading to these awards originated from the CHIPS and Science Act. Yevgeny Raitses will lead efforts to incorporate 2D materials into next-generation semiconductors, while Alastair Stacey will research diamond materials for sensors that need to work in harsh environments. These awards underscore PPPL’s expertise in plasma, which is a key part of making microelectronics and the highest quality, lab-grown diamond.

A new generation of microelectronics research begins at PNNL.