From millions of virtual structures to three real breakthroughs
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Updates every hour. Last Updated: 21-May-2025 23:10 ET (22-May-2025 03:10 GMT/UTC)
Researchers at Karolinska Institutet in Sweden have developed a technique that enables efficient delivery of therapeutic proteins and RNA to cells. The method, presented in Nature Communications, shows promising results in animal studies to deliver gene editors and protein therapeutics.
Hematopoietic stem cells (HSCs) can differentiate into any blood cell. However, as HSCs age, they are more likely to differentiate into platelets and myeloid cells. This age-dependent shift is poorly understood due to a lack of marker genes. Now, scientists from the University of Tokyo present the Clusterin (Clu) gene as a novel biomarker of HSC aging. This allows easy identification of aged HSCs, shedding light on the biological mechanisms of aging.