When a glass of red wine arrives at the table, most drinkers make a snap judgment before taking a sip. Is the color deep enough? Does the hue suggest quality, or raise a red flag? For years, that visual scrutiny has posed a challenge to an emerging category of wine grapes. Interspecific hybrid varieties – cultivars bred by crossing multiple Vitis vinifera species to withstand disease, cold and the mounting pressures of climate change – have been viewed with skepticism by winemakers and sommeliers who worried that the wines they produce simply don't look the part.

Conventional CAR-T therapy requires collecting T cells, genetically modifying them in the laboratory, and reinfusing the engineered cells—a process that takes weeks and costs lots of money. A new review systematically examines in vivo CAR-T approaches that perform this entire reprogramming process inside the patient's body using targeted delivery systems. The article analyzes delivery platforms, evaluates clinical translation progress, and discusses strategies for overcoming key challenges, including off-target effects, immunogenicity, and T cell exhaustion.

Build systems are a fundamental component of modern software development. Dependency-related errors represent a significant portion of build errors in large-scale projects. However, existing tools for detecting these errors struggle to achieve both high performance and accuracy. In a new study, researchers developed mkcheck2, which reduces performance overhead by up to 99.7% while maintaining accuracy through an efficient eBPF-based system call tracing method and incremental analysis, thereby making continuous dependency verification practical.

A versatile transistor enables AI hardware to filter image data before analysis and adapt to different tasks, reducing energy consumption with little loss of accuracy.

Differences in forest structure and function, measured by aircraft, can help explain how birds use existing habitats, how they respond to threats, and which communities may be most at risk as forests change. As deforestation, climate change and land-use pressures continue to reshape tropical forests, researchers say the method could help land managers anticipate ecological change and prioritize strategies that protect both species diversity and ecosystem function.

Research led by the University of Oxford has found that rapid economic growth brought major gains in access to electricity and cleaner cooking in India, but growing reliance on coal-fired power has contributed to worsening outdoor air pollution and a sharp rise in urban air-pollution-related deaths. The study has been published today (25 Sept) in Nature Cities.

AI-assisted TB screening could reduce costs and bring diagnostic support to underserved communities, helping narrow gaps in public healthcare in the Philippines.