Molecular basis of multicentric carpotarsal osteolysis (MCTO) nephropathy: Pathogenic MAFB accumulation and PI3K/AKT signaling
Peer-Reviewed Publication
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The researchers coupled the vehicle-track dynamics model with the UIUC model to provide a comprehensive description of vehicle-induced ballast settlement — encompassing both its full evolution and cumulative dynamic effects. Special emphasis was placed on the influence of sleeper voids.
Researchers in Japan showed that growing Eu-doped GaN on a semipolar GaN plane selectively forms highly efficient Eu luminescent centers while suppressing inefficient Eu clusters. The approach increased room-temperature red emission by 3.6 times, reduced efficiency droop, and points to brighter, wavelength-stable red LEDs for monolithically integrated full-color micro-LED displays using the GaN materials platform.
Identifying and analysing climate risks is a necessary function of governments, but researchers at Adelaide University’s Environment Institute argue such processes will not lead to effective action without taking additional steps to understand which risks are considered unacceptable by the community and prioritising responses accordingly.
Researchers from the School of Electronic Science and Engineering at Southeast University, led by Prof. Zhenhua Ni and Prof. Junpeng Lu, have developed a pioneering computational spectrometer recently published in PhotoniX. The device utilizes a silicon photonic "Vernier Caliper" concept to overcome the fundamental trade-off between device footprint, bandwidth, and resolution. Operating within an ultra-compact footprint of only 55*35 µm2, the spectrometer achieves an expansive bandwidth exceeding 160 nm and an average algorithm-enhanced spectral resolution of 1.35 pm. This performance establishes a record-breaking bandwidth-to-resolution-to-footprint ratio of over 61.5 µm-2, demonstrating a significant advance for integrated spectrometers.
This breakthrough is achieved through a deep co-design of photonic hardware and computational science, moving beyond simple algorithmic compensation. The hardware architecture features cascaded Trapezoidal Subwavelength Grating Microring Resonators (TSWG-MRRs) that utilize dispersion engineering to suppress resonant periodicity. This deterministic design allows the device to scan a working window over 16 times larger than a standard microring's free spectral range. The system treats the intrinsic resonance peaks as orthogonal measurement bases and integrates an Nvidia Jetson GPU-accelerated unit to achieve real-time reconstruction. The team successfully resolved 49 absorption lines of hydrogen cyanide (H13C14N) with an accuracy exceeding commercial benchtop optical spectrum analyzers, validating its potential for gas sensing, chemical analysis, and lab-on-a-chip applications.