Tech & Engineering
Updates every hour. Last Updated: 8-Nov-2025 04:11 ET (8-Nov-2025 09:11 GMT/UTC)
Evolution-assisted engineering boosts succinic acid production in E. coli
Nanjing Agricultural University The Academy of ScienceA research team has successfully combined adaptive laboratory evolution (ALE) with metabolic engineering to create a strain of Escherichia coli that produces succinic acid (SA) from glycerol at significantly higher yields.
- Journal
- BioDesign Research
Engineered yeast unlocks sustainable production of cannabinoids and analogs
Nanjing Agricultural University The Academy of ScienceA research team has engineered the nonconventional yeast Yarrowia lipolytica to produce cannabinoids and their analogs, offering a sustainable alternative to plant extraction.
- Journal
- BioDesign Research
Boosting production of pharmacologically relevant diterpenoids through engineered miltiradiene synthase
Nanjing Agricultural University The Academy of ScienceA team of researchers has uncovered how subtle structural changes in terpene synthases can dramatically improve the biosynthesis of miltiradiene, a critical intermediate in the production of pharmacologically valuable compounds such as tanshinone IIA, triptolide, and carnosic acid.
- Journal
- BioDesign Research
Cofactor engineering with phosphite dehydrogenase enables flexible regulation of lactate-based copolymer biosynthesis in E. coli
Nanjing Agricultural University The Academy of SciencePeer-Reviewed Publication
A research team has developed an innovative platform for producing lactate-based biodegradable plastics by harnessing a phosphite dehydrogenase (PtxD)-driven NADH regeneration system in Escherichia coli.
- Journal
- BioDesign Research
Yeast-engineered biocatalysis enables stepwise production of MDMA and analogs
Nanjing Agricultural University The Academy of ScienceA research team has developed the first reported bioproduction method for 3,4-methylenedioxymethamphetamine (MDMA, commonly known as Ecstasy) and related methamphetamine derivatives using a combination of yeast-based bioconversion, biocatalysis, and chemical reduction.
- Journal
- BioDesign Research
Protein engineering advances unlock pathways to greener industrial biocatalysts
Nanjing Agricultural University The Academy of ScienceA research team has summarized the latest advances in protein engineering strategies aimed at enhancing enzyme stability under harsh industrial conditions.
- Journal
- BioDesign Research