How mechanical stress can accelerate bone destruction in periodontitis
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 07:16 ET (26-Oct-2026 11:16 GMT/UTC)
Excessive bite force does not cause alveolar bone loss but significantly worsens it when combined with periodontitis, report researchers in a new study. While traumatic occlusion has long been suspected to exacerbate periodontitis, the molecular mechanisms behind this link were poorly understood. Now, using mouse models of both conditions separately and combined, the researchers conducted comprehensive gene expression analysis across multiple periodontal tissues, identifying key inflammatory pathways upregulated in bone when both conditions were present.
Conical intersections are crucial molecular switching points in light-driven reactions, but accurately predicting them usually requires computations. A researcher from Shibaura Institute of Technology has developed a new low-cost quantum chemistry method that can simultaneously describe ground and excited molecular states while efficiently locating these elusive structures. The approach reproduces benchmark geometries with strong accuracy and enables practical simulations of photochemical processes, making it promising for applications in photocatalysis, solar cells, and biological light-response studies.
Researchers in Japan found that lower plasma copper levels and reduced white matter volume in individuals with autism spectrum disorder were associated with clinical symptom scores, including social symptom severity. Using a mouse model, they show that developmental copper deficiency disrupts brain vascular and metabolic signaling, impairs oligodendrocyte maturation and myelination, and alters social behavior through mitophagy and mTOR suppression.
Researchers at Tohoku University look beyond the life-taking venomous stings of box jellyfish, and focus on life-creating processes in a new comprehensive study of their reproductive traits.
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