Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Dec-2025 02:11 ET (16-Dec-2025 07:11 GMT/UTC)
Collagenase-like protease (Clp) enhances the toxic effect of Streptococcus suis serotype 2 (SS2). Clp increases the permeability of the blood–brain barrier by disrupting tight junctions and inducing apoptosis of brain endothelial cells. Clp triggers brain endothelial cell apoptosis through cell receptor ligand apoptosis and mitochondrial apoptosis pathways, partially dependent on its enzyme activity.
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