24-Jul-2026 Human embryo editing: 10 years of breakthroughs and challenges Higher Education Press Over the past decade, the field of human embryo editing has witnessed remarkable advancements and triggered significant ethical debates. Since the first reported editing in 2015, the field has shown promise for treating genetic disorders and studying early development, the field has shown promise for treating genetic disorders and studying early development, but it still grapples with safety concerns, including off-target effects, mosaicism and the long-term impacts of genetic alterations, as well as ongoing ethical controversies. Journal Protein & Cell
24-Jul-2026 Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system Higher Education Press T cell receptor-engineered T (TCR-T) cell therapy has shown promising clinical potential, yet accurate assessment of patient suitability remains challenging because current genomic and transcriptomic approaches do not directly capture physiological antigen presentation or authentic T-cell responsiveness. Here, we developed a rapid and standardized Jurkat-based reporter platform, termed the TCR-SignalFunc system, for functional evaluation of TCR-T cell therapeutic potential. Journal Protein & Cell
24-Jul-2026 Structural basis of Arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement Higher Education Press The Arp2/3 complex, a core component of the actin filament network, mediates the formation of branching points upon activation by nucleation-promoting factors (NPFs), which is essential for diverse cellular processes such as lamellipodial protrusion and directional migration. Journal Protein & Cell
22-Jul-2026 Reducing muscle protein activity strengthened bone health University of Missouri-Columbia According to researchers from the University of Missouri School of Medicine, reducing the activity of myostatin, a protein that normally stops muscles from growing too big, improved bone density in a preclinical mouse model of pregnant women with osteogenesis imperfecta. Journal Bone
22-Jul-2026 Reducing muscle protein activity strengthened bone health University of Missouri-Columbia According to researchers from the University of Missouri School of Medicine, reducing the activity of myostatin, a protein that normally stops muscles from growing too big, improved bone density in a preclinical mouse model of pregnant women with osteogenesis imperfecta. Journal Bone
21-Jul-2026 Molecular insights into Candida auris glycosylphosphatidylinositol transamidase Higher Education Press Candida auris is a rising global health threat due to multidrug resistance, emphasizing the urgent need for novel antifungal strategies. The C. auris glycosylphosphatidylinositol transamidase (GPI-T) complex is the key enzyme that mediates the attachment of GPI anchors to target proteins. Journal Protein & Cell
21-Jul-2026 New genetic "guardian" discovered: Potential breakthrough in reversing male reproductive aging Higher Education Press Researchers have identified a critical genetic pathway involving the protein FOXO1 that maintains the health of the epididymis, a vital component of the male reproductive system. The study reveals that the age-related decline of this pathway drives cellular senescence and infertility. Furthermore, experimental treatments using specialized stem cells demonstrated the ability to restore this pathway, offering a promising new strategy for preserving male reproductive longevity. Journal Protein & Cell
21-Jul-2026 More than a cellular patch: rhMG53 discovered as a novel c-met agonist for heart protection： Higher Education Press The gold standard for treating a heart attack—rapidly restoring blood flow—comes with a deadly catch. This sudden reoxygenation often triggers a secondary wave of tissue destruction known as ischemia/reperfusion injury. Now, a study published in Protein & Cell unveils a revolutionary strategy to neutralize this "reperfusion shock" using a recombinant protein called human MG53 (rhMG53). Journal Protein & Cell
21-Jul-2026 Plasma proteomic signatures of childhood adversity Higher Education Press Childhood adversity has been linked to many types of diseases; however, the underlying biological mechanisms remain inadequately explored, hindering the development of preventive programs and targeted interventions. The plasma proteome has become a promising tool for investigating the mechanisms underlying disease development in recent years. What are the plasma proteomic signatures of childhood adversity, and how do they contribute to the associations of childhood adversity with diseases? Journal Protein & Cell
