Microplastic pollution in the Gulf of Mexico is contaminating Texas oysters and causing biochemical stress and physiological damage
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Updates every hour. Last Updated: 30-Oct-2026 22:16 ET (31-Oct-2026 02:16 GMT/UTC)
Growth delay, muscle hypotonia, craniofacial abnormalities, cognitive impairment, and heart defects: these are the key manifestations of Kabuki syndrome, a rare genetic disorder affecting 1 in 30,000 newborns. The condition is caused by mutations in a gene (KMT2D) that encodes a protein called MLL4, which is involved in organizing chromatin — the complex of DNA and proteins within the cell nucleus. A promising breakthrough in understanding the disease and its underlying causes comes from research led by the University of Trento (UniTrento), revealing a previously unknown mechanism that links chromatin alterations to defects in the cellular response to mechanical stimuli.
How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led jointly by researchers from CeMM and the University of Oxford identifies NUDT5 as an unexpected regulator of drug sensitivity and reveals that its role has nothing to do with its enzymatic activity. Published in Nature Communications (DOI 10.1038/s41467-026-74489-9), the findings combine targeted protein degradation, medicinal chemistry and genetic experiments to uncover a previously hidden layer of thiopurine biology and further challenge traditional views of how enzymes function in cells.
Ovarian ageing is a primary cause of declining female fertility, characterised by a reduction in both oocyte number and quality. A new study from Professor Lin Liu and Professor Zhengmao Zhu’s team at the College of Life Sciences, Nankai University, published in Science China Life Sciences, reveals that induced pluripotent stem cells (iPSCs) reprogrammed from granulosa cells of reproductively aged mice exhibit a markedly reduced capacity to differentiate into primordial germ cell‑like cells (PGCLCs). This defect cannot be rescued by simply improving mitochondrial function, but inhibition of the ERK/MAPK signalling pathway significantly enhances differentiation efficiency. The findings provide new insights into the decline of germ‑cell regenerative potential during ovarian ageing and identify a potential intervention target for future fertility restoration using autologous cells.
As mice age, their total egg reserve collapses around tenfold. Yet, according to a new study in Nature Ageing, the proportion of eggs in the brief window where a follicle is shifting from dormant to growing stays constant throughout life, at approximately 14%. The finding challenges the perception that ovaries are a passive reservoir of eggs. The authors of the study reframe the female reproductive organ as an actively monitored system and suggest the ovary could be counting its own egg supply because of a yet-to-be-identified hormone or neuronal signalling. The discovery was possible thanks to the first complete three-dimensional map of how a mammalian ovary changes across its reproductive lifespan.