When meat doesn’t matter: Female Guinea baboons do not prefer males who are better at acquiring or sharing meat
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Updates every hour. Last Updated: 30-Oct-2026 21:16 ET (31-Oct-2026 01:16 GMT/UTC)
Researchers identified functional noncoding variants in an enhancer of TBX1 that may contribute to tetralogy of Fallot, the most common cyanotic congenital heart defect. Using whole-genome sequencing in 428 patients and blood vessel organoids, the study shows that disruption of this enhancer reduces TBX1 expression and impairs vascular development linked to the cardiac outflow tract.
A team led by Academician Ge Junbo and Professor Sun Aijun at Fudan University reveals that environmental eustress attenuates doxorubicin-induced cardiotoxicity while enhancing antitumor effects via a hypothalamus-heart-tumor axis. Eustress upregulates hypothalamic BDNF, which activates TrkB receptors on cardiac resident macrophages to inhibit CCL2 secretion, thereby reducing pro-inflammatory Ly6Chigh monocyte/macrophage infiltration into heart tissue. In hepatocellular carcinoma models, eustress also downregulates tumor microenvironment CCL2, decreasing immunosuppressive G-MDSCs and M2 macrophages while increasing cytotoxic CD8+ T cells and M1 macrophages. CCL2 is identified as a core dual target for cardio-oncology intervention, providing a safe and accessible non-pharmacological strategy for preventing chemotherapy-related cardiac toxicity in cancer patients.
Finnish researchers have taken an important step toward long-lasting production of renewable chemicals and fuels using photosynthetic microorganisms. By entrapping cyanobacteria engineered for ethylene production in thin nanocellulose films, the researchers enabled sustained ethylene production for more than four months and generated approximately twice as much ethylene as comparable suspension cultures.
A research team led by Ganggang Chen at the First Hospital of Shanxi Medical University has published a comprehensive review in ENT Discovery detailing the clinical applications of rotational chair testing for vestibular disorders. The paper synthesizes evidence on the test’s physiological basis, standardized protocols, diagnostic performance, and expanded use cases, positioning it as an indispensable tool that bridges the frequency domain gap between standard caloric testing and video head impulse tests (vHIT). The findings provide a roadmap for broader, more standardized implementation of the modality to improve diagnosis and rehabilitation guidance for patients with dizziness and vertigo.
A research team led by Wenyan Li and Yanfeng Jiang at Fudan University has published study in ENT Discovery, quantifying how lifestyle influences hearing impairment and dissecting the mediating roles of inflammatory and metabolic biomarkers. Based on 441,844 UK Biobank participants followed for a median of 14.22 years, the study found that adherence to an ideal lifestyle was associated with a 14% lower risk of incident hearing impairment compared with a poor lifestyle. Mediation analyses showed metabolic biomarkers—particularly body mass index (BMI) and high-density lipoprotein cholesterol (HDL-c)—accounted for the largest share of the association, while inflammatory pathways played a smaller secondary role. The findings offer mechanistic evidence supporting lifestyle-based interventions for hearing impairment prevention.
Around one in six people experience infertility, with irregular or absent ovulation among the most common causes. The drug clomiphene citrate has long been a mainstay of fertility treatment, but a growing body of Adelaide University research is raising safety concerns about higher cumulative doses.