In a single IV injection, a gene therapy targeting cBIN1 can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves survival.

Helical structures are ubiquitous across biology, from the double-stranded helix of DNA to how heart muscle cells spiral in a band. Inspired by this twisty ladder, researchers from Hiroshima University’s Graduate School of Advanced Science and Engineering have developed an artificial polymer that organizes itself into a controlled helix. Helical structures are ubiquitous across biology, from the double-stranded helix of DNA to how heart muscle cells spiral in a band. Inspired by this twisty ladder, researchers from Hiroshima University’s Graduate School of Advanced Science and Engineering have developed an artificial polymer that organizes itself into a controlled helix. 

A study sheds new light on how Toxoplasma gondii parasites make the proteins they need to enter a dormant stage that allows them to escape drug treatment.

A new USC Stem Cell study has identified key gene regulators that enable some deafened animals—including fish and lizards—to naturally regenerate their hearing. The findings could guide future efforts to stimulate the regeneration of sensory hearing cells in patients with hearing loss and balance disorders. The study focuses on two cell types in the inner ear: the sensory cells that detect sound, and the supporting cells that create an environment where sensory cells can thrive. In highly regenerative species such as fish and lizards, supporting cells can also transform into replacement sensory cells after injury—a capacity absent in humans, mice and all other mammals. The scientists determined how genes normally only found in the sensory cells can be re-activated in the supporting cells of regenerative species. To achieve that, the scientists determined how the genome is folded in the sensory cells and supporting cells of the inner ears of regenerative zebrafish and green anole lizards. They then compared DNA control elements for sensory genes in zebrafish and green anole lizards to those in mice, which cannot replace sensory hearing cells after injury. Their experiments revealed a class of DNA control elements known as “enhancers” that, after injury, amplify the production of a protein called ATOH1, which in turn induces a suite of genes required to make sensory cells of the inner ear. Using CRISPR the scientists deleted five of these enhancers in zebrafish, impairing both the formation of sensory hearing cells during development and their regeneration following injury.

 

A University of Houston psychology researcher is reporting that children with autism focus on faces differently than other children, especially in the early stages of visual processing. His findings may lead to improvement in face processing for those with the neurodevelopmental condition.