How exercise fights implant infections: Muscle hormone “musclin” unveiled as a key defender
Peer-Reviewed Publication
Updates every hour. Last Updated: 31-Oct-2026 05:15 ET (31-Oct-2026 09:15 GMT/UTC)
Periprosthetic joint infection (PJI) is a devastating complication of joint replacement surgery. A new study in the Journal of Sport and Health Science discovers that musclin, a hormone released by muscles during exercise, directly binds to macrophages. This interaction rewires cellular metabolism, significantly boosting the macrophages' ability to clear dead cells (efferocytosis). This process effectively resolves inflammation, reduces bacterial burden, and promotes tissue repair, offering a promising "exercise-mimetic" therapeutic strategy for managing implant-associated infections.
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