Completely artificial proteins that produce bioluminescence can serve as a non-invasive method for bioimaging, diagnostics, drug discovery, and more.

MBARI researchers have discovered a remarkable new species of sea slug that lives in the deep sea. Nicknamed the "mystery mollusc," the nudibranch Bathydevius caudactylus swims through the ocean’s midnight zone with a large gelatinous hood and paddle-like tail, and lights up with brilliant bioluminescence. Thanks to MBARI's advanced underwater technology, researchers were able to prepare a comprehensive description of the natural history of this amazing animal.

Ovarian cancer is more deadly than any other type of female reproductive organ cancer. It is estimated that in 2024, in the U.S. alone, more than 12,000 women will die from the disease because available therapies are not effective. To help overcome this striking deficit in women’s health, ARPA-H has awarded a team at the Wyss Institute at Harvard University a contract under its Sprint for Women’s Health program to develop “iNodes” – implantable lymphoid organs containing patients’ immune cells – as an entirely novel form of personalized immunotherapy to treat ovarian cancer.

This review explores the role of lysosomal stress in pancreatic diseases, particularly diabetes mellitus. Lysosomes, crucial for cellular metabolism, help restore homeostasis under stress. Emerging evidence shows their involvement in metabolic diseases affecting organs like the liver and heart. The review discusses lysosomal biology, immune and metabolic functions, and how lysosomal stress contributes to pancreatic disease pathogenesis, with the aim of advancing potential treatments.