The International Society for Stem Cell Research (ISSCR) has opened registration and abstract submissions for the ISSCR 2027 Annual Meeting, taking place 15-18 June 2027 at Moscone West in San Francisco, California, USA. Marking the 25th anniversary of the ISSCR Annual Meeting, this hallmark event will bring together the global stem cell community to share groundbreaking discoveries, explore transformative technologies, and advance the future of stem cell science and regenerative medicine. 

Scientists have identified and activated a small group of neurons responsible for the initiation of learned movements. The study used cutting-edge techniques to not only “read” brain activity down to the level of individual cells, but “write” patterns that allowed researchers to control movement.

Every organ and tissue progressively loses function as it ages, but aging tissues retain a latent capacity for rejuvenation. A new study, led by Wyss Institute Core Faculty member George Church, used gene expression data and machine learning to develop a novel “transcriptomic age predictor,” which pinpoints the “transcriptional age” of cells. Using this predictor as a readout in an over-expression screen, the team identified the RNA processing factor SRSF1and demonstrated that it can rejuvenate several “hallmarks of aging,” and significantly increase the healthspan and lifespan of aged mice. 

Scientists at the University of Bath (UK) have produced a new azulene-based fluorescent probe that is five times brighter than the original molecule. Their research has uncovered the tiny molecular changes needed to transform both the colour and brightness of the probes, paving the way for more powerful imaging tools for detecting diseases such as Alzheimer's, Parkinson’s and cancer.

In the 1970s, researchers began to observe drastic amphibian declines in Brazil’s Atlantic Forest, a global hotspot of frog biodiversity. For decades, these disappearances remained a mystery. Now, new research from scientists at the Smithsonian’s National Zoo and Conservation Biology Institute and Pennsylvania State University, published today in the journal Molecular Ecology, points to amphibian chytridiomycosis, a devastating infectious disease, as the likely culprit.

A team from IRB Barcelona, in collaboration with the Sant Joan de Déu Research Institute and the Pediatric Cancer Center Barcelona at Sant Joan de Déu Hospital, has described a mechanism by which a cancer-related protein can activate regions of DNA that normally remain silenced.

Using the Drosophila fruit fly, the researchers demonstrated that this activation depends on collaboration with another protein, enabling the study of a mechanism that is difficult to isolate in human cells.

The study, published in G3: Genes|Genomes|Genetics, may help explain previous observations in prostate cancer and B-cell acute lymphoblastic leukemia.

The stability of the human gut microbiome relies on interactions between different bacterial species. However, the specific molecular mechanisms of these interactions, particularly among non-dominant species, remain largely unexplored. In a new study, a research team from Hosei University, Japan, has discovered such an interaction, in which Escherichia coli detects metabolites from Bifidobacterium through a special sensory mechanism, forming a non-dominant communication network. This finding helps explain how gut microbiome diversity is maintained.

Open-access 3D model of the world’s largest woodpecker brings an extinct Mexican bird into the public eye.