A new lipid recipe helps mRNA delivery stay on target
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 19:16 ET (28-Oct-2026 23:16 GMT/UTC)
Even a local mRNA injection can produce unwanted expression in the liver. Researchers have redesigned the lipid nanoparticles that carry mRNA to reduce this spillover in mice while preserving expression in injected muscle. The formulation also supports repeated dosing and improves the confinement of expression after local brain and eye delivery.
Molecular biologist Elke Deuerling from the University of Konstanz receives the Dr. K. H. Eberle Prize 2026, worth 100,000 euros. The funding will support a basic research project that takes a fresh look at the origins of neurodegenerative diseases such as Alzheimer’s and Parkinson’s and explores new avenues for their treatment.
Soils are among the planet's largest carbon reservoirs, yet salinity and land degradation threaten their ability to store carbon and support agriculture. Improving carbon storage in salt-affected farmland could therefore offer a dual benefit: restoring soil health while supporting climate change mitigation.
Salk scientists find a receptor called SRF3 that manages cellular iron levels while simultaneously regulating the plant’s immune response. Discovery reveals previously unknown mechanism that allows plants both to absorb this essential nutrient and defend against microbes, informing future crop resilience efforts. Study also provides insights into cellular mechanisms that could be relevant in mammalian cells and key signaling proteins in cancer and beyond.