A Trojan horse for artificial amino acids
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Dec-2025 13:11 ET (23-Dec-2025 18:11 GMT/UTC)
Researchers from ETH Zurich have modified a bacterial transport system so that it can efficiently introduce large quantities of unnatural amino acids into cells, disguised as a kind of Trojan horse.
All organisms manufacture their proteins from the same 20 amino acids. Additionally, unnatural amino acids can be used to produce designer proteins with new functions.
The new system allows the efficient biotechnological mass production of these designer proteins. Applications range from precise therapeutics and more efficient catalysts to improved imaging techniques.
Computer simulations revealed the detailed mechanism of how the protein "dynamin" works to form small vesicles within cells.
While dynamin uses GTP hydrolysis energy to change shape, it was unclear how this leads to membrane constriction. Simulations showed that instead of simply tightening, dynamin "loosens" (expands) at a certain stage to generate the force needed to narrow the surrounding membrane tube.
This study provides a clearer explanation for membrane deformation and vesicle formation processes in cells, offering insights for artificial nano-device design.
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