Endangered Pacific pocket mice, native to Southern California, were once thought to be extinct until a tiny remnant population was rediscovered in the mid-1990s. San Diego Zoo Wildlife Alliance established a conservation breeding and reintroduction program to save the species from extinction. Though there has been significant success with breeding and reintroduction, the species is still at risk of losing genetic diversity, which reduces its survival and reproduction. In a new study published in the prestigious scientific journal Science on August 21, San Diego Zoo Wildlife Alliance researchers demonstrate how genetic rescue can be used as an effective strategy for the conservation of this species. This strategy includes introducing Pacific pocket mice from genetically distinct populations for breeding purposes to boost genetic diversity and, in turn, the health of the population.  

New research, published today in the journal Science, shows how lysosomes — organelles that act like cells’ waste disposal system — respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.  

Researchers have discovered that the slow, steady physical forces of tissues pushing and pulling on developing organs are just as important as genes and biochemistry in shaping how organs form in animal embryos.

As the world’s population ages at an unprecedented rate, the field of longevity research is surging to the forefront of science and investment, highlighted by the rapid growth of events like the Aging Research and Drug Discovery (ARDD) conference. Major pharmaceutical companies and record-breaking funding are accelerating breakthroughs in aging biology, with cutting-edge AI technologies playing a central role. Insilico Medicine stands out as a global leader in AI driven drug discovery and aging research, leveraging advanced AI to discover aging biomarkers, therapeutic targets, and novel interventions—achievements showcased at ARDD 2025 alongside top scientists and innovators. Through ongoing collaboration and innovation, Insilico and its partners are paving the way toward the ultimate goal: achieving healthy longevity for everyone on the planet.

Harvard physicists have developed a computational method that can uncover the rules that cells use to self-organize, translating the complex process of cell growth into an optimization problem a computer can solve.