Weaning stress rewires immune translation through GC-rich codons and gut microbes in piglets
Peer-Reviewed Publication
Updates every hour. Last Updated: 27-Oct-2026 22:16 ET (28-Oct-2026 02:16 GMT/UTC)
A Zhejiang University-led team used ribosome profiling, RNA sequencing, and 16S rRNA sequencing to study immune translation in healthy and weaning piglets. Weaning triggered widespread translational reprogramming of immune genes and a shift toward GC-ending codons. Gut microbiota from weaned piglets also showed GC-enriched codon profiles and was linked to host immune gene translation. The findings suggest a previously unrecognized association between microbiota composition and codon-usage-linked translational control during early-life stress.
The EU Nature Restoration Regulation adopted in 2024 establishes the restoration of ecosystem functions as an objective of stream restoration. But can conventional measures that focus primarily on restoring the physical structure of rivers and streams fulfil this task? A meta-analysis by an international research team coordinated by the Helmholtz Centre for Environmental Research (UFZ) shows that this is not necessarily the case. Although restoration measures can improve stream structure and biodiversity, important ecological processes such as nutrient uptake and organic matter decomposition do not necessarily recover. In their study published in Global Change Biology, the researchers therefore recommend incorporating functional indicators more systematically into monitoring and assessments of restoration success and targeting restoration measures more specifically at the functions they are intended to restore.
The International Society for Stem Cell Research (ISSCR) is pleased to announce that its 2029 Annual Meeting will take place 26-29 June 2029 in Kyoto, Japan. The meeting will be held with the support of the Center for iPS Cell Research and Application (CiRA), Kyoto University, and the Japanese Society for Regenerative Medicine (JSRM), bringing the world’s leading stem cell scientists, clinicians, industry innovators, and other stakeholders together in one of the most influential centers for stem cell research and regenerative medicine.
The ISSCR Annual Meeting is the premier global gathering for stem cell science showcasing discoveries across the breadth of the field, from fundamental biology and emerging technologies to disease modeling and clinical translation. The 2029 meeting will provide an exceptional opportunity to highlight Japan’s scientific leadership while fostering international collaboration and accelerating progress across the field.
Baby manta rays escape predators by avoiding them until they grow large enough for a face-off, a new study has found. Tracking data shows that young giant manta rays in Central America strictly stick to comparatively safe coastal areas for the first few years of their life. When they’re large enough that natural enemies are a lesser concern, they leave these sanctuaries and embark on journeys spanning hundreds of kilometers. This shift in space use allows mantas to grow in safety before facing another type of danger in the open oceans: industrial fisheries and vessel strikes in unprotected waters. The authors say underwater corridors are needed to protect adult mantas on their treks.