In the development of Parkinson’s disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson’s disease, and established a link between the auditory processing and movement areas of the brain, according to a study published November 4^th in the open-access journal PLOS Biology by Pei Zhang from the Huazhong University of Science and Technology in Wuhan, China, and colleagues.

New research has updated our understanding of how sugars, known as glycans, help immune cells move into skin in the inflammatory disease, psoriasis

Researchers identified that immune cells, which have their own cell surface glycocalyx, shed this layer to help them move from the blood and into tissues in inflammatory skin disease, changing the previous understanding that it was only the blood vessel wall that altered its glycocalyx layer to aid this process.

Designing drugs to alter the movement of immune cells between the blood and tissues is a potential way to treat both infections and inflammatory diseases. Therefore, this research may alter the approach taken to develop drugs targeting the movement of immune cells into tissues.    

The rates of bloodstream infections caused by drug-resistant bacteria will increase substantially across Europe in the next five years, driven largely by aging populations, according to a new paper published November 4^th in the open-access journal PLOS Medicine by Gwenan Knight of the London School of Hygiene and Tropical Medicine, UK, and colleagues.

As global oyster populations decline and fisheries collapse, archaeologists may be able to inform effective management with valuable, long-term perspectives of the human-oyster connections stretching back millennia.