Extra sets of chromosomes make cells more mobile
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Jun-2026 02:16 ET (28-Jun-2026 06:16 GMT/UTC)
Researchers at Tulane University School of Medicine have discovered that if animal cells gain an extra set of chromosomes, a condition known as polyploidy, they activate a stress signaling pathway that causes them to become more mobile and capable of engulfing neighboring cells with normal chromosome numbers. The study, to be published April 21 in the Journal of Cell Biology (JCB), could provide new ways to target polyploid cancer cells, which are thought to promote tumor aggressiveness and therapy resistance.
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