Scientists unlock clues to new treatments for muscular dystrophy
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Updates every hour. Last Updated: 19-Jun-2025 11:10 ET (19-Jun-2025 15:10 GMT/UTC)
Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells hijack various cellular functions to find and exploit energy and other resources, including a group of enzymes that help normal cells maintain a balance of energy.
These enzymes, called creatine kinases (CK), allow cells to transport energy produced at the mitochondria to where it is needed throughout the cell. Studies of breast cancer cells have highlighted the importance of a type of CK called ubiquitous mitochondrial creatine kinase (uMtCK).
New research published in Structure will serve as the foundation for a collaborative team of Sanford Burnham Prebys and Mayo Clinic investigators to design and develop novel small molecules that selectively inhibit uMtCK to treat breast cancer.Splitting water into hydrogen and oxygen holds promise for producing clean hydrogen fuel, but the process uses more energy than theoretical calculations suggest. Researchers developed a sophisticated new technique to watch water molecules before and during the chemical reaction. They found the molecules flip immediately before producing oxygen. The insights help explain why the process uses so much energy and could lead to improved catalysts for more efficient, practical water-splitting technologies.
Cement manufacturing and repair could be significantly improved by using biocement-producing bacteria, but growing the microbes at construction sites remains a challenge. Now, researchers report a freeze-drying approach in ACS Applied Materials & Interfaces that preserves the bacteria, potentially allowing construction workers to ultimately use powder out of a packet to quickly make tiles, repair oil wells or strengthen the ground for makeshift roads or camps.