Targeting Casitas B-lineage lymphoma-b (CBLB), Insilico Medicine announced the nomination of ISM3830, its 23rd AI-empowered preclinical candidate (PCC) since 2021, in late November 2025, which demonstrated low toxicity risks, favorable ADME/PK profiles, as well as induction of long-term tumor immunity, cracking the bottleneck in metabolism and absorption of previously reported CBLB inhibitors.

 

Shortly beforehand, the discovery process and evaluation of CBLB inhibitors with a different scaffold were published in the Journal of Medicinal Chemistry. The paper highlights Compound 10, a potent, orally available lead compound with novel scaffold promising druggability, providing an AI-driven optimization roadmap for CBLB inhibition strategies.

The Jahn–Teller effect is a well-explored phenomenon in solid-state physics. In a new development, researchers from Waseda University, Japan, focused on spinel-type compounds with the formula AV₂O₄, discovering a phenomenon in which a structural phase transition occurs simultaneously with magnetic ordering in Co₁₋ₓFeₓV₂O₄. This innovation holds fundamental scientific interest and is expected to open new avenues for applications in quantum information.

Adhesives are essential in various industries and have widespread use. However, conventional petroleum-based adhesives rely heavily on the petrochemical industry and pose environmental risks due to harmful emissions and limited reusability. In a new study, researchers developed a novel photo-switchable smart adhesive based on materials derived from rose oil. It is both eco-friendly and highly reusable, while exhibiting great adhesion to a variety of surfaces. This innovative adhesive paves the way for more sustainable and smart material technologies.

China, Tianjin-Researchers at Nankai University have 3D-printed soft hydrogel thermocell “power patches” that can hug skin and devices, turning gentle temperature differences into electricity. By Combining 3D printing and immersion activation strategies, they “sculpt” microstructured hydrogel thermocell surfaces that grip rough, moving heat sources and boost power output several-fold. These patches can also serve as self-powered touch and motion sensors, suggesting that customizable wearable power supplies could quietly harvest waste heat from bodies and irregular heat sources for future sustainable, human-integrated electronics.

In fusion research, the plasma core must be heated to about one hundred million degrees, but heat naturally spreads outward, making it important to slow this spreading as much as possible. Turbulence that appears together with the heat also moves outward. A research team at the National Institute for Fusion Science used the Large Helical Device to study this process and identified turbulence that acts as a mediator, rapidly distributing heat across the plasma. When rapid heating was applied, this mediator became stronger and caused the heat to spread almost instantly. The team also showed for the first time that turbulence plays two roles, both carrying heat and connecting distant regions. These findings reveal how sudden heat spreading occurs and provide a basis for predicting and controlling heat transport in future fusion reactors.

A research team at the Center for Neuroscience Imaging Research (CNIR) within the Institute for Basic Science (IBS), together with Sungkyunkwan University (SKKU), has developed a new class of ultra-thin, flexible bioelectronic material that can seamlessly interface with living tissues. The researchers introduced a novel device called THIN (Transformable and Imperceptible Hydrogel-Elastomer Ionic-Electronic Nanomembrane). THIN is a membrane just 350 nanometers thick that transforms from a dry, rigid film into an ultra-soft, tissue-like interface upon hydration.