Topology-driven upconversion networks for low-power STED microscopy
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Jun-2026 14:16 ET (21-Jun-2026 18:16 GMT/UTC)
Scientists in China have engineered topology-driven energy transfer networks in lanthanide-doped upconversion nanoparticles to dramatically reduce the laser power needed for stimulated emission depletion (STED) microscopy. By spatially separating sensitizers and emitters in core–shell nanoparticles, they enhanced energy migration, boosted emission, and improved optical switching efficiency. Their design achieves STED microscopy imaging with significantly lower excitation and depletion intensities, paving the way for low-power, photostable super-resolution imaging in life sciences and nanophotonics.
Recently, a research team led by Academician Lijun Wang at CIOMP under UCAS has systematically reviewed the latest advancements in transfer printing (TP) technology. The team detailed its practical applications in integrating III-V semiconductor devices into photonic integrated circuits (PIC), demonstrating its significant potential for developing high-performance, high-reliability PICs. Their work provides crucial theoretical guidance for improving transfer yield and precision, while also offering forward-looking insights into current technical challenges and future development directions for this technology.
An electrode for structural batteries was developed by combining carbon nanotubes (CNT) with quartz woven fabric (QWF), demonstrating the potential for structural batteries applicable to the aerospace and defense industries.
Despite the long-standing reputation of each, as well as distinct underlying physics, laser speckle contrast imaging (LSCI) and imaging photoplethysmography (IPPG) reach concordance on functional cerebral haemodynamics. The unified, heartbeat-resolved, camera-based readout offers fast, wide-field assessment of cortical perfusion for the operating theatre.
In the field of polyoxometalate chemistry, organophosphonate covalently modified polyoxometalates have recently emerged as a promising frontier. These hybrid materials not only broaden the structural diversity of conventional polyoxometalate derivatives and address the inherent stability limitations of polyoxometalates, but also allow for the design of improved properties tailored to diverse applications. This review provides a comprehensive summary of recent advances in organophosphonate covalently modified polyoxometalates research, with a particular focus on their structural features, functional properties, and prospective research directions.
Polyoxometalates are promising inorganic drugs with antiviral activity; however, they pose a risk to humans because of their potential accumulation in the body. Polyoxometalates encapsulated with berberine from a traditional Chinese herb may exhibit lower cytotoxicity. In this study, the antiviral effects of four berberine-based organic–polyoxometalate hybrids (BR-POMs) on BHK-21 and PK-15 cells were evaluated in vitro using encephalomyocarditis virus (EMCV) or pseudorabies virus (PRV) models. The collected cells were used for quantitative polymerase chain reaction analysis. The supernatants were collected to quantify the viral loads using a TCID50 assay in vitro. EC50 and CC50 were determined through dose–response experiments, and the EC50/CC50 ratio was used as a selectivity index to measure the antiviral activity. The results demonstrate that all BR-POMs exhibited certain antiviral activity. The BR-POMs did not exert toxicity against the EMCV- or PRV-infected cells at the tested concentration (CC50 > 40 μM). Notably, BR-EuSiW (EC50 15.07 μM, CC50 651.2 µM, SI 43.21) exerted antiviral effects by acting on the virus at its biosynthesis stage, thereby inhibiting virus proliferation in a dose-dependent manner. This study demonstrates that organic–polyoxometalate hybrids represent a new strategy for developing antivirals against EMCV.