On-chip targeted cell killing via unprecedented high-efficiency singlet oxygen generation
Peer-Reviewed Publication
Updates every hour. Last Updated: 18-Jun-2026 23:16 ET (19-Jun-2026 03:16 GMT/UTC)
A team from Tsinghua University reports Au–TiO₂ metasurfaces that convert visible light into singlet oxygen at high speed and extremely high local density. By combining quasi-BIC field confinement with hot-carrier transfer across an ultrathin interface, the device produces molar-level singlet oxygen locally within seconds, which is surprisingly ~10⁶ times that achieved by conventional approaches. Besides, the on-chip generator enables wavelength- and pixel-selective cytotoxicity for targeted tumor cell killing in photodynamic therapy.
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