Insilico team employed advanced molecular modeling techniques in combination with the company’s proprietary generative AI-based chemistry engine, Chemistry42, to efficiently design highly selective FGFR2/3 inhibitors featuring a novel core structure. This research, recently published in the Journal of Medicinal Chemistry, provides an innovative approach for the discovery and development of next-generation cancer therapies targeting FGFR2/3.

A new way to grow stem cells may help them release more of the signaling proteins they use to repair tissue, potentially improving future treatments.

Real-time monitoring of additive concentrations in acidic copper plating solution is critical for ensuring process stability and reliability in integrated circuit manufacturing. Traditional detection systems rely on bulky rotating platinum disk electrodes (2–3 mm diameter) that consume large solution volumes to maintain unrestricted flow at high speeds, complicating operational workflows and limiting miniaturization. A team of scientists has addressed these challenges by developing a novel electrochemical microfluidic workstation that combines 3D-printed microfluidic chips with static platinum ultra-microelectrodes. By integrating microfluidic programmed mixing, the system reduces single-test solution consumption to 220 microliters. Calibration curves based on additive effects on copper deposition kinetics enable concentration detection with average relative errors below 10%. Their work is published in the journal Industrial Chemistry & Materials on June 26.

Cell sheet preparation for use in tissue engineering and regenerative therapies could be significantly improved with the use of thermo-responsive polymer brushes, adjusted in length and density according to specific cell types

- University of Leicester scientists analyse the chemical composition of corals to spot the signs of deforestation

- Corals absorb trace elements in water into their skeletons, which provides a proxy for nearby soil erosion

- Fills a huge gap in environmental data on deforestation impacting coastal ecosystems

- University of Leicester’s science and innovation park to lead on a European Space Agency project to build a Double-Walled Isolator (DWI) to support analysis of extra-terrestrial samples

- Samples could be stored and handled and initially analysed in the DWI, to reduce the risk of cross contamination on Earth

- Work has started with funding of €5 million

In a paper published in National Science Review, a research team led by Chinese scientists quantifies changes in dissolved carbon storage within China's lakes and reservoirs alongside dissolved carbon fluxes in rivers over the past three decades, systematically revealing how climate change, anthropogenic disturbances, and water chemistry factors collectively drive the dynamics of dissolved carbon in inland waters. The study finds that dissolved carbon storage across China's inland waters has increased significantly during this period, with riverine carbon fluxes primarily driven by climate and human factors, while lake and reservoir carbon storage is dominated by water chemistry controls.