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Updates every hour. Last Updated: 18-Jun-2025 21:10 ET (19-Jun-2025 01:10 GMT/UTC)
Breakthrough of DPP-1 Inhibitor in decreasing the exacerbation frequency of bronchiectasis (Lancet Respir Med)
National Center for Respiratory MedicineIn this March 2025, The Lancet Respiratory Medicine (JCR Q1, IF: 38.7), the leading journal in the fields of respiratory and critical care medicine, published a phase 2 clinical study article on China's first DPP-1 inhibitor, HSK31858, led by Academician Nan-shan Zhong and Professor Wei-jie Guan from the First Affiliated Hospital of Guangzhou Medical University and Guangzhou National Laboratory. The article entitled "Effects of the DPP-1 Inhibitor HSK31858 in Adults with Bronchiectasis in China (SAVE-BE): A Phase 2, Multicentre, Double-Blind, Randomised, Placebo-Controlled Trial.", by focusing on non-cystic fibrosis bronchiectasis patients, marks a significant breakthrough in China's bronchiectasis treatment.
The article presents the efficacy and safety data of the DPP-1 inhibitor in Chinese bronchiectasis patients, offering a new therapeutic strategy. Results show that compared with traditional treatments, HSK31858 significantly improves patient symptoms and reduces acute exacerbation frequency. This finding holds promise for bronchiectasis patients and will further advance the field of respiratory medicine.
- Journal
- The Lancet Respiratory Medicine
Comprehensive genomic insights into food-derived lactic acid bacteria reveal key roles in human health
Science China PressRecently, the research team led by Professor Heping Zhang at the Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education, Inner Mongolia Agricultural University, published a groundbreaking study in the prestigious journal Science Bulletin. Titled "A Genomic Compendium of Cultivated Food-Derived Lactic Acid Bacteria Unveils Their Contributions to Human Health", the study details the development of the comprehensive genomic dataset of food-derived lactic acid bacteria (FLAB). By systematically revealing their diversity and potential applications in food fermentation and human health, this research provides valuable scientific insights and foundational support for future studies and practical applications of LAB.
- Journal
- Science Bulletin
In an advance for promethium production, researchers get a new view of the element’s properties
DOE/US Department of Energy- Journal
- Nature
Even preschoolers recognize hypocrites
SWPS UniversityEven preschool children can recognize a hypocrite. And, just like adults, they don't have the best opinion of such people: they assess hypocrites more negatively than they do other people who break commonly accepted rules, a study conducted by researchers from SWPS University shows.
- Journal
- Developmental Science
Unlocking auction efficiency: a deep dive into Federal Reserve's MBS auction mechanisms
Shanghai Jiao Tong University Journal CenterPurpose
We estimate the marginal cost curve of each dealer in each auction, based on structural models of the multiunit discriminatory-price auction.
Design/methodology/approach
Auction theory has ambiguous implications regarding the relative performance of three formats of multiunit auctions: uniform-price, discriminatory-price and Vickrey auctions. We evaluate the performance of these three auction formats using bid-level data of the Federal Reserve’s purchase auctions of agency MBS from June 2014 through November 2014.
Findings
Our results suggest that neither uniform-price nor Vickrey auctions outperform discriminatory-price auctions in terms of the total expenditure. However, Vickrey auctions outperform discriminatory-price auctions in terms of efficiency, with the efficiency gain around 0.74% of the surplus that dealers extract on average.
Originality/value
To the best of our knowledge, this paper provides the first structural analysis of the auctions used by the Federal Reserve in implementing its monetary policies.
- Journal
- China Finance Review International
Incentive mechanism design via smart contract in blockchain-based edge-assisted crowdsensing
Higher Education PressResearch team introduced CHASER, an incentive mechanism for blockchain-based EMCS systems. It ensures budget balance, truthfulness, rationality, and high social welfare. Simulations show a 42% increase in social welfare and high task completion rates.
- Journal
- Frontiers of Computer Science
Cobalt phosphide-loaded biochar synthesis using phosphate-accumulating yeast and its application as an electrocatalyst
Osaka Metropolitan UniversityAn Osaka Metropolitan University study shows that phosphorus accumulation in Saccharomyces cerevisiae mutant yeast cells improves the activity of the resulting biochar catalyst.
- Journal
- Biotechnology Reports
New approach to materials synthesis—with quick validation by a robotic lab
DOE/US Department of Energy- Journal
- Nature Synthesis
Study reveals partisan divide in perceptions of Ford-Kavanaugh hearings
University of California - Irvine- Journal
- Personality and Social Psychology Bulletin