Article Highlights
Updates every hour. Last Updated: 1-May-2025 11:08 ET (1-May-2025 15:08 GMT/UTC)
Dissection of intratumor microbiome-host interactions at single-cell level in lung cancer
Tsinghua University PressThis study investigated the heterogeneity of host-microbiome interactions at the single-cell level by integrating six single-cell transcriptomic datasets using single-cell analysis of host-microbiome interactions in lung cancer.
- Journal
- hLife
The novel anthraquinone compound Kanglexin prevents endothelial-to-mesenchymal transition in atherosclerosis by activating FGFR1 and suppressing integrin β1/TGFβ signaling
Higher Education PressAtherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events. A key process in atherosclerosis is the endothelial-to-mesenchymal transition (EndMT), which involves the transformation of endothelial cells into mesenchymal cells, contributing to plaque formation and vascular dysfunction. The novel anthraquinone compound Kanglexin (KLX) has been investigated for its potential to prevent EndMT in atherosclerosis by targeting the fibroblast growth factor receptor 1 (FGFR1) and suppressing the integrin β1/transforming growth factor-beta (TGFβ) signaling pathway. This study provides insights into the molecular mechanisms underlying the protective effects of KLX against EndMT and atherosclerotic progression.
- Journal
- Frontiers of Medicine
Homing in on spinning gluons: New study nearly nixes the negative
DOE/Thomas Jefferson National Accelerator FacilityResearchers have been working for decades to understand the details of where the proton gets its intrinsic angular momentum, otherwise referred to as its spin. Recently, there have been indications that the spin contribution of the gluons could either be positive or negative. Now, a new approach that avoids assumptions and re-analyzes observational data with lattice quantum chromodynamics points strongly toward a positive gluon spin contribution, ∆g, to the proton spin.
- Journal
- Physical Review Letters
- Funder
- DOE/US Department of Energy
Tackling the threat of drug-resistant E. coli in China
China Agricultural University- Journal
- One Health Advances
Unlocking new hope for treating liver disease with genetics
First Hospital of Jilin UniversityResearchers explored Mendelian randomization to identify novel drug targets for metabolic dysfunction-associated steatotic liver disease (MASLD). This approach could revolutionize therapies for a condition affecting over one-third of adults globally.
- Journal
- eGastroenterology
- Funder
- University of Hong Kong's Seed Fund for Basic Science
Scientists develop magnesium-enriched nanofiber patches for safer wound healing
Shibaura Institute of TechnologyHealing severe wounds requires strong, safe, and effective dressings to prevent infections. Researchers at the University of Lincoln and Shibaura Institute of Technology have developed a new type of wound patch by adding magnesium chloride to polyurethane nanofibers. These enhanced patches are stronger, more blood-compatible, and exhibit superior antibacterial properties than conventional ones, making them a game-changer for wound care. This innovative approach could improve healing outcomes and care for patients with serious injuries.
- Journal
- International Journal of Nanomedicine
High stability and fast calibration-free temperature measurement based on light-induced thermoelastic spectroscopy
Ultrafast Science- Journal
- Ultrafast Science
Waste to wealth: Pomelo peel can be used for electricity generation and sensing devices
University of Illinois College of Agricultural, Consumer and Environmental SciencesPomelo is a large citrus fruit commonly grown in Southeast and East Asia. It has a very thick peel, which is typically discarded, resulting in a considerable amount of food waste. In a new study, University of Illinois Urbana-Champaign researchers explore ways to utilize waste pomelo-peel biomass to develop tools that can power small electric devices and monitor biomechanical motions.
- Journal
- ACS Applied Materials & Interfaces
- Funder
- National Institute of Food and Agriculture, National Institute of Food and Agriculture
Plant extract inspires new chemistry and new early lead against triple-negative breast cancer
Emory UniversityChemists at Emory University invented a reaction to streamline the total synthesis of a compound, phaeocaulisin A, extracted from a plant used for centuries in traditional Chinese medicine. In laboratory dish experiments conducted with biologists at Winship Cancer Institute of Emory University, the researchers showed the compound’s efficacy against HER2-positive breast cancer cells and triple-negative breast cancer cells. An analogue of the compound the chemists constructed boosted this efficacy.
- Journal
- Journal of the American Chemical Society
- Funder
- U.S. National Science Foundation