New Review Integrates Human, Animal, and Cellular Evidence to Reframe AD as a Triad-Centered Disorder

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by memory loss, cognitive impairment, and widespread neuronal dysfunction. Although amyloid and tau pathologies have dominated the field for decades, growing evidence suggests that AD arises from broader homeostatic failures rather than a single molecular trigger.

Asthma is a chronic inflammatory airway disease affecting over 300 million people worldwide, and viral infections remain among the strongest triggers of acute exacerbations. Enterovirus D68 (EV-D68), in particular, has been repeatedly linked to severe asthma attacks in children, yet the host mechanisms that determine susceptibility remain poorly defined.

On October 3, 2025, a multicenter team from Shenzhen University, Xiangya Hospital of Central South University, Zhujiang Hospital of Southern Medical University, Wuxi People's Hospital Affiliated to Nanjing Medical University, among others jointly reported a novel noninvasive method for quantifying tumor fibrosis based on preoperative enhanced CT. This method enables precise assessment of the tumor microenvironment characteristics of pancreatic cancer and individualized guidance for chemotherapy regimens. It covers scenarios such as prognostic stratification of resectable pancreatic cancer, efficacy prediction of AG chemotherapy regimens for unresectable pancreatic cancer, and cross-cohort validation of multimodal imaging. The paper, titled "Noninvasive Computed Tomography-Based Quantification of Tumor Fibrosis Predicts Pancreatic Cancer Response to Gemcitabine/Nab-Paclitaxel", was published in Research (Research, 2025, 0937, DOI: 10.34133/research.0937).

According to a new meta-analysis, acute-on-chronic liver failure (ACLF) can develop even in patients with previously compensated liver disease and is associated with a high risk of death. Reviewing studies published over the past decade, researchers found that short-term mortality remains high, despite shifts in underlying causes, with alcohol-related liver disease increasingly replacing viral hepatitis. The findings underscore the need for stronger prevention efforts and improved clinical management.

Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma (HCC). However, their precise roles and underlying mechanisms remain insufficiently characterized and require further investigation. This study aimed to explore the prognostic significance of CCCRGs in HCC, and to investigate the mechanism by which they promote the progression of HCC.