18-Aug-2026 Fasting turns brain lysosomes into reservoirs for TCA cycle metabolites Higher Education Press Lysosomes were once viewed mainly as cellular waste disposers, but are now recognized as key hubs for nutrient sensing and metabolic signaling. Still, what lysosomes contribute metabolically inside high-demand neurons in the intact brain remains elusive. Journal Life Metabolism
18-Aug-2026 A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction Higher Education Press Aging is a major risk factor for chronic diseases, and calorie restriction (CR) is a robust non-pharmacological intervention that can extend health span in multiple species. Alternative splicing (AS) generates multiple RNA isoforms from a single pre-mRNA and becomes dysregulated with age; intriguingly, prior work suggests that CR can attenuate age-associated splicing noise. What has remained unclear is whether AS responses to CR are coordinated across tissues and whether they scale with the level of restriction. Journal Life Metabolism
18-Aug-2026 Gestational progesterone is linked to improved menstrual regularity after Higher Education Press Polycystic ovary syndrome (PCOS) affects 6%−20% of reproductive-aged women, and is commonly accompanied by irregular menstrual cycles and anovulatory infertility. The mechanisms underlying menstrual cycle irregularities associated with PCOS, and how they may change after pregnancy remain incompletely understood. Journal Life Metabolism
18-Aug-2026 Integrating heart imaging and proteomics identifies drug targets for cardiovascular diseases Higher Education Press As an emerging branch of clinical medicine, microbiota medicine has attracted worldwide attention from clinicians, medical educators, patient communities, and industry. However, this developing field still lacks consensus on its fundamental principles as well as guidelines for clinical and educational practice. An expert panel was convened by the journal Microbiota Medicine Research at the 2025 CHINAGUT Conference to develop the principles and practice guidelines of microbiota medicine.
18-Aug-2026 FPR2 drives intestinal epithelial repair after injury Higher Education Press The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial regeneration following injury, such as that induced by chemotherapy or radiation, the underlying regulatory mechanisms remain incompletely understood. Journal Life Metabolism
18-Aug-2026 Post-meal SPARC level predicts who benefits most from the Mediterranean diet Higher Education Press A new study published in Life Metabolism reports that a single post-meal blood biomarker, 1-hour postprandial SPARC (SPARC-1H), can predict who will benefit most from adopting a Mediterranean diet. The discovery provides one of the clearest examples to date of how precision nutrition can identify individualized dietary responses using a simple blood test rather than complex multi-omics models. Journal Life Metabolism
18-Aug-2026 Molecular characterization of HIV-1 subtypes and primary drug resistance mutations in Bangladesh: Insights from 2019 data Bentham Science Publishers Acquired Immunodeficiency Syndrome (AIDS) caused by Human Immunodeficiency Virus (HIV) has been a significant public health concern for over four decades. Globally, more than 75 million individuals have been infected, with an estimated 32.7 million deaths attributed to AIDS-related complications. Even though there are continuous advancements in treatment and prevention, in 2019, about 1.7 million new infections were reported, which represents a 23% decline in new diagnoses compared to 2010, The high frequency of the D121 polymorphism, though not directly linked to treatment failure, reflects underlying genetic variability that may influence future resistance pathways Journal The Open AIDS Journal
18-Aug-2026 Glycine acts as a signal to boost insulin secretion via ER calcium homeostasis Higher Education Press Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine levels are associated with insulin resistance, type 2 diabetes (T2D), and obesity across diverse populations. However, the molecular mechanism linking glycine to insulin production has remained incompletely understood, limiting therapeutic applications. Journal Life Metabolism
18-Aug-2026 Proline-producing enzyme P5CS identified as a key driver of metabolic fatty liver disease Higher Education Press Metabolic dysfunction-associated steatotic liver disease (MASLD), a spectrum of liver conditions ranging from simple steatosis to steatohepatitis (MASH), fibrosis, and cirrhosis, represents a global health epidemic with no approved pharmacotherapies. Journal Life Metabolism
18-Aug-2026 DDAH1 controls hepatic lipid metabolism under fasting Higher Education Press The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a process often accompanied by transient hepatic steatosis. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key enzyme metabolizing asymmetric dimethylarginine (ADMA), has been shown to protect against NAFLD under nutrient-overload conditions. However, its role in the physiological context of fasting remained elusive. Journal Life Metabolism
