27-Jul-2025 Fangchinoline from traditional Chinese medicine targets T cells in Sjögren’s syndrome, inducing apoptosis via oxidative stress and Akt inhibition FAR Publishing Limited A study led by Yubo Xu at Tongji University reveals that Fangchinoline (Fan), a compound from Stephania tetrandra, triggers oxidative stress-induced DNA damage and apoptosis in Jurkat T cells while inhibiting Akt signaling. This dual mechanism highlights Fan’s potential as a therapeutic agent for Sjögren’s syndrome (SS), where T cell infiltration drives disease progression. Journal Current Molecular Pharmacology
27-Jul-2025 Breakthrough review unveils molecular mechanisms and emerging therapies for sarcopenia in aging populations FAR Publishing Limited A comprehensive review in Current Molecular Pharmacology explores sarcopenia’s molecular pathways and cutting-edge interventions. Led by Priyanka Prajapati and team, the study highlights oxidative stress, mitochondrial dysfunction, and promising treatments like exercise, nutraceuticals, and hormone therapy. "Targeting these pathways could revolutionize sarcopenia management," said Prajapati. Journal Current Molecular Pharmacology
27-Jul-2025 Breakthrough study reveals key mechanism behind therapy-resistant leukemia stem cells FAR Publishing Limited A groundbreaking study in Current Molecular Pharmacology uncovers how deeply quiescent leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) evade therapy by suppressing mitochondrial complex I (MC-1) and relying on fatty acid oxidation (FAO). Led by Dr. Nyam-Osor Chimge and Dr. Michael Kahn, the research identifies the CBP/β-catenin antagonist ICG-001 as a potential strategy to force differentiation and eliminate resistant cells. "Targeting this metabolic vulnerability could revolutionize CML treatment," said Dr. Kahn. Journal Current Molecular Pharmacology
26-Jul-2025 Tomato’s genetic shield against aluminum stress uncovered Nanjing Agricultural University The Academy of Science Acidic soils pose a major threat to crop yields due to toxic aluminum ions, especially in sensitive plants like tomato. Journal Horticulture Research
26-Jul-2025 Designer fungi: Genetic “dial” fine-tunes mycelium from leather-soft to steel-hard Journal of Bioresources and Bioproducts A Journal of Bioresources and Bioproducts study shows that natural variation in Schizophyllum commune, coupled with glycerol or PEG crosslinking, produces films with specific strengths from 0.03–3 MPa·(m³/kg) and elongations up to 98 %, offering a genetic roadmap for sustainable materials. Journal Journal of Bioresources and Bioproducts
25-Jul-2025 Cracking the genome of a rising biofuel star Nanjing Agricultural University The Academy of Science Camelina (Camelina sativa) is gaining global attention as a climate-friendly biofuel crop, yet its limited genetic diversity poses a challenge for crop improvement. Journal Horticulture Research
25-Jul-2025 Advancements in analytical techniques for angiotensin receptor blockers: A comprehensive FAR Publishing Limited A new review published in Current Pharmaceutical Analysis provides an in-depth look at the latest analytical techniques used for impurity profiling and forced degradation studies of Angiotensin (AT1) Receptor Blockers (ARBs), commonly known as sartans. These drugs are widely used for hypertension treatment. The study highlights the importance of detecting and characterizing impurities to ensure drug safety and efficacy. Journal Current Pharmaceutical Analysis
25-Jul-2025 Nanotechnology-enhanced electrochemical biosensors revolutionize insulin detection FAR Publishing Limited A new review published in Current Pharmaceutical Analysis highlights the advancements in nanotechnology-based electrochemical biosensors for detecting insulin and other hormones. These biosensors offer high sensitivity, selectivity, and rapid detection, crucial for diabetes management. The study explores recent developments, challenges, and future prospects in this field.
25-Jul-2025 Molecular mechanism uncovered: Beta-Carotene keeps enzymes active under heavy load Technical University of Munich (TUM) Enzymes are vital to metabolism and drive countless biological processes in humans, plants, and industry. Yet, when overwhelmed by excess substrate, some enzymes slow down — a phenomenon known as substrate inhibition. This can hinder drug effectiveness and industrial efficiency. Researchers at the Technical University of Munich (TUM) have explored this mechanism and found that beta-carotene may help counteract it. Journal Nature Communications
25-Jul-2025 Ancient desert berry unlocks new hope for diabetes treatment Zhejiang University In a potential game-changer for diabetes treatment, researchers have uncovered remarkable benefits from an obscure desert plant.
