Although manual small incision cataract surgery (SICS) is widely practiced in countries of the global South, there is no publicly available surgical video dataset for this operation, leaving a critical gap in cataract surgery research. Therefore, an international research team at Sankara Eye Foundation India led by the University Hospital Bonn (UKB) and the University of Bonn has developed the first automated phase detection using AI in SICS. The results of the study have now been published in the renowned journal Scientific Reports. In parallel, the international research team is now launching a global AI competition at the MICCAI 2025 conference in Daejeon (South Korea), in which AI algorithms for surgical phase detection will compete against each other. The submission deadline is 15^th of August 2025.

If you’ve ever sat waiting at the doctor’s office to give a blood sample, you might have wished there was a way to find the same information without needles.

But for all the medical breakthroughs of the 20^th century, the best way to detect molecules has remained through liquids, such as blood. New research from the University of Chicago, however, could someday put a pause on pinpricks. A group of scientists announced they have created a small, portable device that can collect and detect airborne molecules—a breakthrough that holds promise for many areas of medicine and public health.

Senescence, aging, and age-related diseases represent complex biological phenomena with significant impacts on human health, and metabolism and metabolomics play pivotal roles in understanding their mechanisms and interventions. This comprehensive review integrates multiscale perspectives to elaborate on the intricate relationships among metabolism, cellular senescence, organismal aging, and diseases such as cardiovascular disorders, neurodegenerative diseases, diabetes, and osteoporosis.

ARMC5, a cytoplasmic protein encoded by a gene rich in armadillo (ARM) repeat sequences, has emerged as a critical regulator of cellular processes, with implications spanning tumor suppression, endocrine disorders, and immune modulation. Ubiquitously expressed across human tissues, ARMC5 lacks enzymatic activity but mediates protein-protein interactions through its ARM repeats and BTB/POZ domain. These structural features enable it to act as a scaffold for ubiquitin ligase complexes, influencing protein degradation via the ubiquitin-proteasome system (UPS). Initially identified as a tumor suppressor linked to bilateral macronodular adrenocortical disease (BMAD), ARMC5’s role has expanded to include associations with meningiomas, primary aldosteronism (PA), renal cell carcinoma (RCC), and embryonic development.