Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in ACS Nano, how proteins in cells can be controllably activated through heating, an effect that can be used to initiate programmed cell death.

A peer-reviewed journal focusing on immunity and inflammation field is now available on Springer Nature platform. “We are proud to announce the launch of Immunity & Inflammation, an innovative and high-profile platform dedicated to cutting-edge research,” share Professor Xuetao Cao and Professor Jules Hoffmann, Co-Editors-In-Chief of the journal. The journal will focus on critical insights across the spectrum of immunology and invites researchers around the world to join in exploring breakthroughs in immunity and inflammation.

Research led by The Ohio State University Wexner Medical Center and College of Medicine explores the ways brain cells communicate, revealing fresh insight into the progression of Alzheimer’s disease.

Colorectal cancer is one of the most common and deadly cancers worldwide, and treatment decisions for older patients remain highly debated. Now, researchers have found that oxaliplatin-based chemotherapy significantly improves survival only in stage III colorectal cancer patients aged 70 or younger. For patients over 70, the drug offered no survival advantage and led to higher rates of treatment discontinuation due to toxicity. Importantly, stage II patients showed no survival benefit at any age.

This study deciphers the characteristics of human spinal cord neural stem cells (hscNSCs) specific to cervical, thoracic, and lumbar segments, and establishes an efficient method for amplifying hscNSCs from different spinal segments. A key finding: when transplanted into rat models with thoracic spinal cord injury (SCI), thoracic hscNSCs show superior therapeutic effects compared to cervical or lumbar hscNSCs. The research clarifies the critical role of segment-specific hscNSCs in spinal cord injury repair, offering valuable insights for targeted SCI treatment strategies.