Researchers from the Institute of Biophysics of the Chinese Academy of Sciences, the Grossman School of Medicine at New York University, and the School of Medicine at Zhejiang University have systematically demonstrated that LAG-3 inhibits T cell activity by positioning itself in close proximity to the T cell receptor (TCR) complex, rather than by simply binding to a ligand.

BUFFALO, NY – July 7, 2025 – A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled “Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience.”

Researchers have developed a new surgical microscope, the Fourier lightfield multiview stereoscope (FiLM-Scope), that captures 48 simultaneous high-resolution views of the surgical field using an array of microcameras. This system enables real-time, high-precision 3D reconstruction with depth resolution down to 11 microns across a broad field of view. Unlike traditional stereoscopic microscopes, which rely on two viewpoints and human depth perception, the FiLM-Scope produces quantitative 3D maps without needing prior training data. This technology has the potential to enhance both manual and robotic microsurgery by providing more accurate, intuitive, and comprehensive visualization during procedures.

China has made remarkable progress in controlling chronic hepatitis B virus (HBV) infection over the past three decades. The prevalence of hepatitis B surface antigen has declined from 9.72% in 1992 to 5.86% in 2020, with a striking reduction from 9.67% to 0.30% among children under five. Universal hepatitis B vaccination has been pivotal, preventing more than 40 million infections and seven million HBV-related deaths since 1992. Nevertheless, an estimated 75 million individuals are currently living with chronic HBV infection in China. Among them, only 59.78% are aware of their infection status, and about 30 million remain undiagnosed. Of those diagnosed, 38.25% (approximately 17 million) meet the criteria for antiviral treatment, yet only 17.33% (about three million) are receiving treatment. To accelerate progress toward the World Health Organization’s elimination targets, China has updated its clinical guidelines to expand treatment eligibility and improve diagnosis and treatment coverage. Moreover, Chinese pharmaceutical companies and academic institutions are actively engaged in developing novel therapies with promising efficacy, aiming to achieve a functional cure. China’s holistic approach, combining evidence-based public health interventions with active clinical management and innovative pharmaceutical development, provides valuable experience for global HBV elimination initiatives. This review aimed to summarize China's progress in HBV control, identify remaining gaps in diagnosis and treatment, and highlight strategic approaches, including public health interventions, clinical policy updates, and pharmaceutical innovation, toward achieving HBV elimination.