Ovarian cancer remains the leading cause of death among cancers affecting the female reproductive system, largely because current treatments are not effective once the cancer has spread (metastasised) beyond the ovaries. A recent study led by Professor Alice WONG, Interim Director of the School of Biological Sciences at The University of Hong Kong (HKU), has identified a critical factor driving this metastasis, offering promising new directions for targeted treatment strategies. The team’s findings have just been published in Protein and Cell and featured as the journal’s cover article, highlighting the significance of their work.

In a significant advancement for stroke care, researchers from HKU Stroke and the Department of Medicine, School of Clinical Medicine at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed) have developed the TRICH score. This innovative clinical tool is designed to help physicians effectively identify intracerebral hemorrhage (ICH) patients who would benefit from early prescription of triple anti-hypertensive medication. The TRICH score addresses a critical need in hypertension care after ICH by facilitating timely and effective blood pressure control. It also has the potential to significantly reduce the risk of ICH recurrence and subsequent strokes. The findings were published in the international journal Neurology.

A comprehensive review published in Genomic Psychiatry examines how corticotropin releasing factor (CRF), an ancient stress neuropeptide, modulates dopamine pathways in nonhuman primates. The research illuminates crucial anatomical differences between rodent and primate brains, potentially explaining why translating rodent-based stress treatments to humans has proven challenging.

New research demonstrates that individuals with depression have a salience network in their brain nearly twice as large as non-depressed controls. This distinctive neural signature predates symptom onset and remains stable regardless of depression severity or treatment, suggesting potential as the first reliable biomarker for identifying depression risk.

A revealing Genomic Press interview with Dr. Yehezkel Ben-Ari unveils how his "Neuroarcheology" concept fundamentally transforms our understanding of brain disorders. This pioneering framework proposes that many neurological conditions reactivate developmental mechanisms, providing new approaches to predict, understand, and treat previously intractable conditions.