Researchers have completed the largest study to date of TCF7L2-related neurodevelopmental disorder (TRND), a rare genetic condition caused by changes in the TCF7L2 gene, which plays an important role in brain development. By analyzing 76 patients from around the world in collaboration with sites across 14 countries and several US cities, including Philadelphia and Boston, the team found that the most common identifying features were speech delay, autism, developmental delays, vision problems such as nearsightedness, and orthopedic issues affecting the muscles and skeleton. Many patients also had distinctive facial features, helping researchers better define the condition and improve recognition and diagnosis. The study, led by Senior Author, David Fajgenbaum, MD, MBA, MSc, and other researchers in the Perelman School of Medicine at the University of Pennsylvania, was recently published in Genetics in Medicine.

Infants born to mothers with depressive symptoms immediately after delivery had a substantially higher risk of dying before their first birthday, according to researchers involved in a Rutgers-led study of more than 414,000 births in New Jersey.

Researchers find that political news consumed outside of work can affect employees' engagement, anxiety and willingness to help co-workers.

About the Study: Intrauterine instillation of 10 mL of mepivacaine (20 mg/mL) significantly reduced pain and improved tolerability during IUD placement compared with instillation of placebo saline.

In this multicenter randomized clinical trial of 370 nulliparous individuals undergoing placement of smaller-diameter IUDs, intrauterine instillation of mepivacaine reduced pain during IUD placement compared with placebo saline and improved tolerability. The findings support mepivacaine instillation as a simple approach that could improve the IUD placement experience.

The 2027 edition of Newsweek’s World's Best Specialized Hospitals ranking once again recognises Gustave Roussy as the leading cancer centre in France and Europe, and the third best worldwide. This distinction highlights the excellence of the Institute’s care and research, as well as the daily commitment of all its professionals.