RMPY-008 delivers a structured digital protocol that combines evidence-based psychological interventions with neuroscience-informed sensory modulation. In a randomized controlled study of 103 participants aged 50-65, RMPY-008:

Reduced depression and anxiety scores and improved resilience and well-being;

Decreased levels of key pro-inflammatory immune mediators: TNF-α, IL-17, IL-23, IL-12, IFN-γ, and MCP-1, indicating a potential coordinated immune response. These immune markers are known to play roles in mood disorders and in neurodegenerative diseases such as Alzheimer’s disease;

Strengthened resting-state connectivity in the fronto-limbic network, especially the insula and prefrontal cortex-areas central to emotion regulation and immune modulation;

Showed a significant correlation between brain connectivity changes and immune changes - a significant association between increased resting state functional connectivity of the right insula seed and medial prefrontal cortex and reduced IL-23, IL-17 and TNF-α pro-inflammatory cytokine levels;

Showed a significant correlation between brain connectivity changes and psychological improvements - significant association between resting state functional connectivity of the right insula seed and key prefrontal areas (mPFC, ACC, and dlPFC) and improvement in depression, well-being and resilience scores;

Exhibited sustained clinical benefit - the trial also included a three-week follow-up period, during which benefits were sustained with only twice-weekly use;

Achieved high adherence and engagement - participants using the app showed 94% adherence, and more than 90% completed over 80% of daily sessions.

A groundbreaking study led by a global research consortium offers new hope for patients with mycetoma, a neglected tropical disease. Researchers using an insect model and transcriptome analysis have unravelled the mechanism of iron regulation between host tissue and the mycetoma grain, a fungal mass characteristic of the disease. This discovery illuminates how the causative fungus invades and develops these protective grains within subcutaneous tissue, paving the way for new drug development and less invasive treatment strategies beyond surgical removal, potentially reducing the burden on patients significantly.